Distribution law and pathological characteristics of cystic degeneration in steroid-induced femoral head necrosis

doi:10.12307/2023.580

Chinese Journal of Tissue Engineering Research ›› 2023, Vol. 27 ›› Issue (31): 4996-5001.doi: 10.12307/2023.580

Distribution law and pathological characteristics of cystic degeneration in steroid-induced femoral head necrosis

Tian Jiaqing1, He Mincong2, 3, Wei Yurou1, He Xianshun1, Zhong Yuan1, Jiang Yulai1, Zhan Zhiwei1, Wei Tengfei1, He Xiaoming2, 3, Wei Qiushi2, 3

1Third Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China; 2Institute of Joint, Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510000, Guangdong Province, China; 3Guangdong Institute of Traditional Chinese Medicine Bone Injury, Guangzhou 510000, Guangdong Province, China

Received:2022-07-11 Accepted:2022-10-12 Online:2023-11-08 Published:2023-01-31
Contact: Wei Qiushi, MD, Associate chief physician, Institute of Joint, Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510000, Guangdong Province, China; Guangdong Institute of Traditional Chinese Medicine Bone Injury, Guangzhou 510000, Guangdong Province, China
About author:Tian Jiaqing, Third Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
Supported by:
National Natural Science Foundation of China (General Program), No. 82274544 (to WQS); Open Projects of Guangdong Institute of Traditional Chinese Medicine Bone Injury in 2021, Nos. GYH202101-01 (to WQS [project participant]) and GYH202101-04 (to WQS); Major Project of "Double First-class" and High-level University Discipline Collaborative Innovation Team of Guangzhou University of Chinese Medicine, No. 2021XK05 (to WQS [project participant]); "Double First-class" and High-level University Discipline Collaborative Innovation Team Cultivation Project of Guangzhou University of Chinese Medicine, No. 2021XK41 (to WQS); 2021 Special Project of Guangdong Provincial Department of Education in Key Fields of Ordinary Universities, No. 2021ZDZX2005 (to WQS); Young Science Foundation of National Natural Science Foundation of China, No. 82004392 (to HMC)

Abstract

Abstract: BACKGROUND: The reduction of mechanical bearing capacity of the femoral head is the main cause of femoral head collapse, and cystic degeneration affects the normal mechanical conduction pathway of the hip joint. However, few studies have explored the relationship between the two in the development of femoral head necrosis.
OBJECTIVE: To discuss the distribution law and pathological characteristics of cystic degeneration in steroid-induced femoral head necrosis based on heat map model and pathological results.
METHODS: Thirty patients (30 hips) who were diagnosed with steroid-induced femoral head necrosis in the Third Affiliated Hospital of Guangzhou University of Chinese Medicine from June to December 2021 were selected as the research objects, and the outline of cystic degeneration of steroid-induced femoral head necrosis was extracted and the contour line was matched to the standard femoral head model to present the contour line as a heat map. Necrosis position and necrosis area of the femoral head were recorded and counted to study the relationship between the two. Hematoxylin-eosin staining was used for histomorphological changes of femoral head specimens.
RESULTS AND CONCLUSION: (1) Based on the heat map of the cystic degeneration of steroid-induced femoral head necrosis and the pathological results of the femoral head, we found that cystic degeneration commonly occurred in the medial and lateral columns of the femoral head after steroid-induced femoral head necrosis. Compared with the area of cystic degeneration of the medial column, the area of cystic degeneration of the lateral column was larger, and with the inward movement of cystic degeneration, its area also decreased. (2) In addition, microfracture lines were scattered around cystic degeneration, which may be one of the important factors affecting the mechanical bearing capacity and stability of the femoral head.

Key words: steroid-induced femoral head necrosis, cystic degeneration, heat map, microfracture, mechanical bearing capacity, distribution law, pathological characteristics

CLC Number:

Tian Jiaqing, He Mincong, Wei Yurou, He Xianshun, Zhong Yuan, Jiang Yulai, Zhan Zhiwei, Wei Tengfei, He Xiaoming, Wei Qiushi. Distribution law and pathological characteristics of cystic degeneration in steroid-induced femoral head necrosis[J]. Chinese Journal of Tissue Engineering Research, 2023, 27(31): 4996-5001.

Figures/Tables 7

References

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Distribution law and pathological characteristics of cystic degeneration in steroid-induced femoral head necrosis

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