Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (28): 5165-5168.doi: 10.3969/j.issn.1673-8225.2011.28.009

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Expression of osteoprotegerin and osteoprotegerin ligand in the focus of spinal tuberculosis

He Yu-ze1, Wang Zi-li2, Ma Teng2, Xin Bing1, Guo Kai-jin1   

  1. 1Department of Orthopedics, Affiliated Hospital of Xuzhou Medical College, Xuzhou  221002, Jiangsu Province, China; 2Department of Orthopedics, Affiliated Hospital of Ningxia Medical University, Yinchuan  750004, Ningxia Hui Autonomous Region, China
  • Received:2011-04-27 Revised:2011-06-01 Online:2011-07-09 Published:2011-07-09
  • Contact: He Yu-ze★, Master, Attending physician, Department of Orthopedics, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, Jiangsu Province, China surgeonhyz@sina. com
  • About author:He Yu-ze★, Master, Attending physician, Department of Orthopedics, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, Jiangsu Province, China surgeonhyz@sina. com

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Abstract:

BACKGROUND: The pathological process of bone tissue hardening in spinal tuberculosis is complex, and the underlying mechanism remains poorly understood.
OBJECTIVE: To investigate the expression of osteoprotegerin (OPG) and OPG ligand (OPGL) in different sections of spinal tubercular infectious focus.
METHODS: The bones resected from patients with spinal tubereculosis were divided into three groups based on their regions: ossified bone, sub-normal bone and normal bone. The average absorbance and positive area percentage of OPG and OPGL in each group samples were detected by PV-6000 two-step immunohistochemical technique.
RESULTS AND CONCLUSION: The average absorbance and positive area percentage of OPG, as well as OPG and OPGL expression in the ossified bone group were significantly greater than in the normal bone group (P < 0.01 or P < 0.05). These findings suggest that changes in OPG and OPGL expression are related to the formation of ossified bone surrounding the focus of spinal tuberculosis.

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