Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (26): 4891-4894.doi: 10.3969/j.issn.1673-8225.2011.26.035

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Treatment of bone defects with autologous bone marrow transplantation combined with bone allograft

Lin Jian-ping, Song Shi-feng, Li Zao-min, Chen Jian-fei, Wu Duo-neng, Xiao Hai-tao   

  1. Department of Orthopedic Trauma, People’s Hospital of Hainan Province, Haikou  570311, Hainan Province, China
  • Received:2011-01-15 Revised:2011-03-17 Online:2011-06-25 Published:2011-06-25
  • About author:Lin Jian-ping★, Master, Associate chief physician, Department of Orthopedic Trauma, People’s Hospital of Hainan Province, Haikou 570311, Hainan Province, China linescu@163.com

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Abstract:

BACKGROUND: Up to now, there are no reports about autologous bone marrow transplantation combined with bone allograft for fresh bone fractures and bone defects in China.
OBJECTIVE: To investigate the mechanism of autologous bone marrow transplantation combined with bone allograft in the treatment of limb fractures.
METHODS: Forty-two cases of limb fractures were randomly divided into three groups: combination group, bone allograft and autologous bone marrow transplantation groups. All patients underwent bone specific alkaline phosphatase (BSAP) and imaging follow-up to observe callus formation and fracture healing.
RESULTS AND CONCLUSION: In the combination group, the rate of callus formation and activity of BSAP were both higher than those in the other two groups at 3, 4, 6 weeks after internal fixation (P < 0.01). The autologous bone marrow transplantation combined with bone allograft probably promotes the early-stage development of the callus, accelerates the bone healing, shorten the hospitalization staying.

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