Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (26): 4864-4867.doi: 10.3969/j.issn.1673-8225.2011.26.029

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Application of bone morphogenetic protein 7 in the orthopedics

Shen Yi, Li Xiao-miao, Wang Wei-li   

  1. Department of Orthopedics, Renji Hospital of Shanghai Jiao Tong University, Shanghai  201615, China
  • Received:2011-01-10 Revised:2011-04-25 Online:2011-06-25 Published:2011-06-25
  • Contact: Wang Wei-li, Master, Chief physician, Professor, Department of Orthopedics, Renji Hospital of Shanghai Jiao Tong University, Shanghai 201615, China drwangwl@126.com
  • About author:Shen Yi★, Master, Attending physician, Department of Orthopedics, Renji Hospital of Shanghai Jiao Tong University, Shanghai 201615, China mrshenyi@126.com
  • Supported by:

    the Non-governmental International Scientific and Technological Cooperation Project of Shanghai Science and Technology Committee, No.09410706100*

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Abstract:

BACKGROUND: Bone morphogenetic protein (BMP) family have the unique ectopic osteoinduction activity. They are related with development of embryonic tissue, functions maintenance and organizational rebuilding. BMPs are important to osteoinduction activity. BMP7, one of BMPs, mainly in bone and kidney, is essential for development of embryonic tissue and organizational rebuilding.
OBJECTIVE: To understand the expression and role of BMP7 in bone development and fracture healing.
METHODS: BMPs relevant articles from Chinese biomedical literature database and Medline database 1990/2010 were retrieved. Then, the development of biology role and regulation path was studied.
RESULTS AND CONCLUSION: With deeply research, BMP7 may play an important role in fracture healing, recessive osteoarthritis, relative osteoarthritis diseases. There are some evidences to indicate that BMPs are profit for prosthesis-bone interfacial osseointegration.

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