Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (21): 3807-3810.doi: 10.3969/j.issn.1673-8225.2011.21.003

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In vivo degradation of beta-tricalcium phosphate/poly-l-lactide composites in cancellous bone

Wang Xiao1,2, Liu Yu-jie1, Chen Xu1   

  1. 1Department of Orthopedics, Chinese PLA General Hospital, Beijing  100853, China
    2Department of Orthopedics, the 62 Hospital of Chinese PLA, Puer  665000, Yunnan Province, China
  • Received:2011-02-12 Revised:2011-04-11 Online:2011-05-21 Published:2011-05-21
  • Contact: Liu Yu-jie, Chief physician, Doctoral supervisor, Department of Orthopedics, Chinese PLA General Hospital, Beijing 100853, China Liuyj301yy@yahoo.com.cn
  • About author:Wang Xiao★, Master, Attending physician, Department of Orthopedics, Chinese PLA General Hospital, Beijing 100853, China; Department of Orthopedics, the 62 Hospital of Chinese PLA, Puer 665000, Yunnan Province, China kinomorn@yahoo.com.cn

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Abstract:

BACKGROUND: To improve the degradation and osteoinductive property of Poly-L-lactide (PLLA) materials, adding inorganic particles such as hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) is a popular choice.
OBJECTIVE: To investigate the in vivo degradation and osteoinductive property of β-TCP/PLLA and PLLA materials in cancellous bone comparatively.
METHODS: Totally 12 adult New Zealand rabbits were implanted PLLA andβ-TCP/PLLA materials into medial and lateral femoral condyle on both sides respectively. The rabbits were sacrificed separately at 6, 12, 24 weeks after operation, 4 animals at each time. The bioabsorption rate, light microscopic and scanning electron microscopic images of PLLA and β-TCP/PLLA materials and surrounding bony tissues were investigated.
RESULTS AND CONCLUSION: β-TCP/PLLA composites contacted more closely with surrounding bone tissues than PLLA. No foreign body reaction was observed. The bioabsorption rate of β-TCP/PLLA that was slower than PLLA in the first 6 weeks accelerated after this period, while more micropores and fine groove in the surfaces and inner part of β-TCP/PLLA composites were observed. No bony replacement was observed in 24 weeks postoperatively. The results show that the degradation rate of β-TCP /PLLA composites that are slower than PLLA in early stage speed up after this period, which is propitious to stablize fixation of implants. Tissue compatibility of β-TCP /PLLA composites is better than PLLA. However, no osteoinductive property of both materials is observed during the study periods.

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