Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (33): 6202-6205.doi: 10.3969/j.issn.1673-8225.2010.33.030

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Animal model of osteoarthritis: Artificial induction versus spontaneous induction

Hu Bo1, Hu Zhi-jun1, Zhang You-wei2, Wang Shi-wei3    

  1. 1 Institute of Spinal Disease, Shanghai University of Traditional Chinese Medicine, Shanghai  200032, China; 2 Department of Orthopaedics and Traumatology,  3 Department of Rehabililtation, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai  200032, China
  • Online:2010-08-13 Published:2010-08-13
  • About author:Hu Bo★, Studying for master’s degree, Institute of Spinal Disease, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China hubo585450@163.com
  • Supported by:

    the Key Subjects of Shanghai Committee of Science and Technology, No. 08JC1418700*

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Abstract:

BACKGROUND: Osteoarthritis (OA) is a retrogressive arthrosis, incidence rate of which increased obviously with the age. Accompanying with the aging of the population, the incidence of this disease appears an upward trend significantly. The etiology and pathogenesis of OA is poorly understood, without cure measures. Thus, corresponding animal models are needed.
OBJECTIVE: To explore preparation, characteristics and application of OA animal models.
METHODS: A computer-based online search of PubMed databases was undertaken to identify the articles about the OA animal models published between January 2004 and October 2009. Meanwhile, Chinese Journal Full-text Database was searched for related Chinese articles published from January 2002 to October 2009. The researches concerning OA were analyzed.
RESULTS AND CONCLUSION: Totally 34 documents addressing the preparation of OA were included in this paper. The OA models could be attained both by artificially and spontaneous induction. The study found that the artificial induced model by surgical method may result in damage to joints, further more, affects experimental results. Non surgical method in inducing OA models mainly used for the research of cartilaginous lesions and drugs. OA models prepared by spontaneous induction are more suitable for the pathological mechanisms and prevention methods of OA. Accordingly, the model preparation is depended on experimental focus. 

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