Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (16): 3007-3010.doi: 10.3969/j.issn.1673-8225.2010.16.039

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Effect of different filling materials on percutaneous vertebroplasty and the image characteristics

Zhao Gang1, Liu Hong-jian2, Zhou Ying-jie1   

  1. 1 Second Department of Spine Surgery, Luoyang Orthopedics Hospital, Luoyang  471002, Henan Province, China; 2 Department of Orthopaedics, First Affiliated Hospital of Zhengzhou University, Zhengzhou   450052, Henan Province, China
  • Online:2010-04-16 Published:2010-04-16
  • About author:Zhao Gang★, Master, Attending physician, Second Department of Spine Surgery, Luoyang Orthopedics Hospital, Luoyang 471002, Henan Province, China lyzgzg@live.cn
  • Supported by:

     Science and Technique Foundation of Henan Province, No. 0524410045*

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Abstract:

BACKGROUND: Now the filling material which is used for the treatment of osteoporotic compression fractures is mainly polymethacrylic acid (PMMA), but the PMMA as a permanent foreign body cannot promote bone regeneration, and has a downward extension of the possibility of mechanical properties with time prolonging, so a new type of filling material used to substitute PMMA is looking.
OBJECTIVE: To investigate the effect and image characteristics of different filling materials on percutaneous vertebroplasty performing on a goat model of osteoporotic compression fracture.
METHODS: Three vertebral fracture models were established on osteoporosis goats by using an appropriate mechanical stress. Under the G-arm X-ray machine, the fractured vertebrae was performed with percutaneous vertebroplasty and then filled with polymethyl methacrylate (PMMA), self-setting calcium phosphate cement (CPC) and recombinant human bone morphogenetic protein-2 (rhBMP-2) /self-calcium phosphate cement.
RESULTS AND CONCLUSION:  ① A total of 36 vertebral bodies of 12 goats were successfully performed with percutaneous vertebroplasty, and there was no significant difference in filling quantity among three materials (3.5±1.8) mL (P > 0.05). Bolus resistance of PMMA was strong, but operative time was short, and the image was great; the bolus resistance of self-CPC and rhBMP-2/self-CPC was weak, operative time was long, but there was no leakage placeholde. ② CT scanning results on the 2nd day after surgery demonstrated that the three materials were disorderly distributed in the vertebral body, showing high-density patching shaping. Six out of 36 vertebral bodies were leakage, which was induced by PMMA (n = 4), self-CPC (n = 1), and rhBMP-2/self-CPC (n = 1). ③ Scanning electron microscope indicated that all materials in the PMMA group were not able to closely bind with host bone, but self-CPC and rhBMP-2/self-CPC were able to closely bind with host bone. The results suggested that rhBMP-2/self-CPC is characterized by long-term operation, short time of bone substitute, and stabilization of reconstructed spine.

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