中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (26): 4895-4898.doi: 10.3969/j.issn.1673-8225.2011.26.036

• 骨与关节临床实践 clinical practice of the bone and joint • 上一篇    下一篇

盐酸氨基葡萄糖联合非类固醇类抗炎药治疗小关节退变伴下腰痛

石  锐1，2，刘  浩1，胡  韬1，丁  琛1   

  1. 四川大学华西医院，1骨科，2科技发展中心，四川省成都市  610041
  • 收稿日期:2011-01-14 修回日期:2011-04-12 出版日期:2011-06-25 发布日期:2011-06-25
  • 通讯作者: 刘浩，博士，教授，博士生导师，四川大学华西医院骨科，四川省成都市610041 Liuhao6304@163.com
  • 作者简介:石锐☆，男，1978年生，云南省昆明市人，汉族，2010年四川大学毕业，博士，助理研究员，主要从事脊柱退变与脊柱动力重建相关基础与临床研究。 dr.shirui@gmail.com

Clinical outcome of glucosamine hydrochloride combined with non-steroid anti-inflammatory drug for degenerative facet joint and low back pain

Shi Rui1,2, Liu Hao1, Hu Tao1, Ding Chen1   

  1. 1Department of Orthopedics,2 Science and Technology Development Center, West China Hospital, Sichuan University, Chengdu  610041, Sichuan Province, China
  • Received:2011-01-14 Revised:2011-04-12 Online:2011-06-25 Published:2011-06-25
  • Contact: Liu Hao, M.D., Professor, Doctoral supervisor, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China Liuhao6304@163.com
  • About author:Shi Rui☆, M.D., Assistant researcher, 1Department of Orthopedics, 2 Science and Technology Development Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China dr.shirui@gmail.com

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被引次数

4

摘要：

背景：盐酸葡萄糖胺对骨关节炎的治疗作用在膝关节已经得到证实，然而盐酸氨基葡萄糖与非类固醇类抗炎药物联用的治疗腰背痛鲜有报道。
目的：探讨盐酸氨基葡萄糖与小剂量非类固醇类抗炎药物联用治疗腰椎小关节退变伴下腰痛的临床效果。
方法：纳入35例小关节退变伴下腰痛患者，给予口服盐酸氨基葡萄糖750 mg，2次/d，外加双氯酚酸钠缓释片75 mg，1次/d，周期8周。使用Oswestry残疾指数、目测类比疼痛评分和SF-36量表在治疗前，治疗完成时和完成治疗后8周进行评估。
结果与结论：33例完成最终的随访，男女比例为1∶2，平均(41.2±10.3)岁。经过治疗，患者的腰痛和腿痛症状，腰椎功能和生活质量均有显著改善和提高(P < 0.05)。提示，盐酸氨基葡萄糖与小剂量非类固醇类抗炎药物联用对小关节退变伴腰痛患者有一定治疗作用。

关键词: 盐酸氨基葡萄糖, 非类固醇类抗炎药, 腰椎, 小关节, 退变, 下腰痛

Abstract:

BACKGROUND: Glucosamine hydrochloride in the treatment of knee osteoarthritis has been confirmed for its safety and reliability due to the function of inflammation control, repairing cartilage and improving joint function. However, glucosamine hydrochloride drugs combined with non-steroid anti-inflammatory drug (NSAID) for low back pain are rarely reported.
OBJECTIVE: To evaluate the clinical effectiveness of glucosamine hydrochloride combined with NSAID for facet joint degeneration and low back pain.
METHODS: A total of 35 patients with degenerative facet joints and low back pain were recruited and received oral administration of glucosamine hydrochloride 750 mg, twice a day, plus diclofenac sodium tablets 75 mg, once a day. The treatment lasted for 8 weeks. Oswestry disability index, visual analog score and SF-36 were used for evaluation prior to treatment, immdiately after treatment and 8 weeks after treatment.
RESULTS AND CONCLUSION: Thirty-three patients completed the final follow-up. The male to female ratio was 1:2, and mean age was (41.2±10.3) years. After treatment, low back pain and leg pain symptoms, lumbar function and quality of life were significantly improved (P < 0.05). Glucosamine hydrochloride combined with low dose NSAID had its effectiveness for degenerative facet joints and low back pain.

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