中国组织工程研究

中国组织工程研究

• 干细胞移植 stem cell transplantation • 上一篇    下一篇

异基因造血干细胞移植后的长期随访

董   敏，吴祥元，林   曲   

  1. 中山大学附属第三医院肿瘤内科，广东省广州市  510630
  • 出版日期:2010-08-06 发布日期:2010-08-06
  • 通讯作者: 吴祥元，硕士，主任医师，中山大学附属第三医院肿瘤内科，广东省广州市 510630 wxy307@yahoo.com.cn
  • 作者简介:董敏★，女，1978年生，河南省新乡市人，汉族，1999年山东医科大学毕业，硕士，主治医师，主要从事造血干细胞移植方面的研究。dm1136@gmail.com
  • 基金资助:

    广东省科技计划项目(2006B36003017)。

Long-term follow-up after allogeneic hematopoietic stem cell transplantation

Dong Min, Wu Xiang-yuan, Lin Qu   

  1. Medical Department of Oncology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou  510630, Guangdong Province, China
  • Online:2010-08-06 Published:2010-08-06
  • Contact: Wu Xiang-yuan, Master, Chief physician, Medical Department of Oncology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China wxy307@yahoo.com.cn
  • About author:Dong Min★, Master, Attending physician, Medical Department of Oncology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China dm1136@gmail.com
  • Supported by:

    the Science and Technology Project of Guangdong Province. No.2006B36003017

PDF

439

被引次数

4

摘要：

背景：近20年来中国的造血干细胞移植工作迅速发展，接受异基因造血干细胞移植后得到治愈的患者越来越多，但关于患者移植后长期随访情况的报道少见。
目的：总结异基因造血干细胞移植后患者的长期随访情况。
方法：对1995/2005在中山大学附属第三医院进行异基因造血干细胞移植的30例患者进行长期随访，总结患者的远期并发症、长期生存率、死亡原因，调查长期生存患者的生活质量。
结果与结论：30例患者的慢性移植物抗宿主病发生率为67%，所有患者均出现不育，1例轻度肺纤维化，无其他远期并发症；移植后2年的无病生存率为60%，2年内未复发的患者均长期生存，生存时间最长的1例已超过14年；12例患者死亡，均发生于移植后2年内，其中5例死于复发，7例为移植相关死亡(均死于感染)；长期生存的患者移植后1年时的生活质量较差，随着生存时间的延长生活质量逐渐改善，5年时的生活质量明显提高，8年时多已拥有较高的生活质量，影响生活质量的主要因素是慢性移植物抗宿主病。

关键词: 造血干细胞, 异基因, 移植, 移植物抗宿主病, 生活质量

Abstract:

BACKGROUND: With the rapid development of hematopoietic stem cell transplantation (HSCT) in China over the last 20 years, more and more patients have been cured after allogeneic HSCT; however, few reports discussed the long-term follow-up results of post-transplantation.
OBJECTIVE: To summarize a long-term follow-up after allogeneic HSCT.
METHODS: There were 30 patients who received allogeneic HSCT at the Third Affiliated Hospital of Sun Yat-sen University between 1995 and 2005. We summarized patients’ long-term complications, survival rate and cause of death and investigated quality of life of long-term survival patients.
RESULTS AND CONCLUSION: In 30 cases, the incidence of chronic graft versus host disease was 67%. Each patient suffered from infertility, and one patient had slight pulmonary fibrosis. No other complications were detected. Disease-free survival two years after transplantation was 60%. Patients without relapse could survive for a long time within two years. The longest surviving time was over 14 years. 12 of 30 patients died, and all of those deaths occurred in two years post-transplantation. Five cases died of recurrence, and other seven patients died of infection. Long-term survival patients had poor life quality one year after transplantation, and their life quality gradually improved with prolonged survival time. The quality of life was improved significantly five years post-transplantation, and the quality of life was high at eight years. The main influential factor for quality of life was chronic graft versus host disease.

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