中国组织工程研究 ›› 2013, Vol. 17 ›› Issue (51): 8795-8800.doi: 10.3969/j.issn.2095-4344.2013.51.003

• 组织工程骨及软骨材料 tissue-engineered bone and cartilage materials • 上一篇    下一篇

可降解高分子网状球囊及磷酸钙骨水泥椎体填充后的力学变化

彭湘涛1,刘训伟1,李  敏1,钟  建2,魏岱旭2,何丹农2,孙  钢1   

  1. 1解放军第二军医大学济南临床医院济南军区总医院医学影像科,山东省济南市  250031;2纳米技术及应用国家工程研究中心,上海市  200241
  • 出版日期:2013-12-17 发布日期:2013-12-17
  • 通讯作者: 孙钢,主任医师,博士,教授,博士生导师,解放军济南军区总医院医学影像科,山东省济南市 250031 cjr.sungang@vip.163.com
  • 作者简介:彭湘涛★,男,1979年生,河南省周口市人,汉族,解放军第401医院放射科,主治医师,现解放军第二军医大学在读硕士,主要从事非血管介入的研究。 Siyuan_peng@163.com
  • 基金资助:

    国家自然科学基金资助(51073173)*

Vertebral bodies implanted with biodegradable reticulated balloon and calcium phosphate cement: Changes in the vertebral biomechanics

Peng Xiang-tao1, Liu Xun-wei1, Li Min1, Zhong Jian2, Wei Dai-xu2, He Dan-nong2, Sun Gang1   

  1. 1 Medical Image Department of General Hospital of Jinan Military Region, Clinical Hospital of the Second Military Medical University, Jinan  250031, Shandong Province, China; 2 National Engineering Research Center for Nanotechnology (NERCN), Shanghai  200241, China
  • Online:2013-12-17 Published:2013-12-17
  • Contact: Sun Gang, M.D., Professor, Chief physician, Doctoral supervisor, Medical Image Department of General Hospital of Jinan Military Region, Clinical Hospital of the Second Military Medical University, Jinan 250031, Shandong Province, China cjr.sungang@vip.163.com
  • About author:Peng Xiang-tao★, Studying for master’s degree, Attending physician, Medical Image Department of General Hospital of Jinan Military Region, Clinical Hospital of the Second Military Medical University, Jinan 250031, Shandong Province, China Siyuan_peng@163.com
  • Supported by:

     the National Natural Science Foundation of China, No. 51073173*

摘要:

背景:寻找具备生物力学性能与生物活性,椎体外渗漏率低的新型椎体填充材料已经成为研究的焦点。
目的:观察植入可降解高分子网状球囊并灌注磷酸钙骨水泥椎体的生物力学性能及骨水泥渗漏率。
方法:将32个猪单椎体标本随机分为4组,其中2组分别经单侧椎弓根注入2.5-3.0 mL聚甲基丙烯酸树脂骨水泥、2.5-3.0 mL磷酸钙骨水泥;其中1组首先植入可降解高分子网状球囊,然后填充2.5-3.0 mL磷酸钙骨水泥;最后1组为正常椎体。观察各组椎体的骨水泥外漏情况,经SCHENCK RSA-250 电子万能试验机测试各组椎体的刚度及强度。
结果与结论:聚甲基丙烯酸树脂骨水泥组椎体强度及刚度明显高于正常椎体(P < 0.05),磷酸钙骨水泥组椎体强度及刚度明显低于正常椎体(P < 0.05),可降解高分子网状球囊联合骨水泥组椎体强度及刚度接近正常椎体(P > 0.05),可降解高分子网状球囊联合骨水泥组骨水泥渗漏率较聚甲基丙烯酸树脂骨水泥组与磷酸钙骨水泥组降低(P < 0.05)。表明植入可降解高分子网状球囊联合磷酸钙骨水泥椎体的生物力学性能最接近正常椎体,骨水泥渗漏率校低。


中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程


全文链接:

关键词: 生物材料, 组织工程骨材料, 骨水泥, 椎体成形术, 椎体后凸成形术, 可降解球囊, 生物力学, 国家自然科学基金

Abstract:

BACKGROUND: It has become a focus to look for new vertebral body filling materials which have the biomechanical property, biological activity and low cement leakage rate.
OBJECTIVE: To investigate the biomechanical characters and cement leakage rate of the vertebral bodies implanted with biodegradable reticulated balloon and calcium phosphate.
METHODS: Thirty-two vertebral bodies from pigs were randomly divided to four groups. For A group, 2.5-3.0 mL polymethacrylate cement was injected into the body through a unilateral thoracic pedicle pathway; for B group, 2.5-3.0 mL calcium phosphate cement were injected by the same protocol; for C group, the biodegradable reticulated balloons filled with 2.5-3.0 mL calcium phosphate cement were implanted; D group, including normal vertebral bodies, was designed as controls. Leakage of bone cement was observed in each group. The load-shift curves were recorded by an electronic universal testing machine (SCHENCK RSA-250).
RESULTS AND CONCLUSION: The stiffness and strength of A group were significantly higher than those of D group (P < 0.05), and the stiffness and strength of B group were statistically lower than those of D group (P < 0.05).
The stiffness and strength of C group, otherwise, were similar with those of D group (P > 0.05). Cement leakage rate of C group was lower than that of A or B group (P < 0.05). Vertebral bodies implanted with biodegradable reticulated balloons may lead to similar biomechanical characters as the normal vertebral bodies and reduce the cement leakage rate.


中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程


全文链接:

Key words: biocompatible materials, absorbable implants, calcium phosphates, biomechanics

中图分类号: