中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (21): 3909-3912.doi: 10.3969/j.issn.1673-8225.2011.21.025

• 生物材料临床实践 clinical practice of biomaterials • 上一篇    下一篇

采用HA130型树脂灌流器血液灌流对维持性血液透析患者微炎症的影响

周西豫1，宋  洁2，张晓东2，李  瑛2，李  辉2   

  1. 1武警陕西总队医院肾脏科,陕西省西安市   710054
    2武警医学院附属医院肾脏病科，天津市   300162
  • 收稿日期:2011-02-12 修回日期:2011-04-11 出版日期:2011-05-21 发布日期:2011-05-21
  • 通讯作者: 张晓东，硕士，主治医师，武警医学院附属医院肾脏病科，天津市 300162 LIHUI2009WUJING@163.com
  • 作者简介:周西豫，女，1976年生，陕西省西安市人，羌族，2000年成都医学院毕业，主治医师，主要从事血液净化的研究。 zxiyu@sohu.com
  • 基金资助:

    天津市自然科学基金资助课题(09JCYBJC09900)。

Effects of hemoperfusion using HA130 resin hemoperfusion apparatus on microinflammatory state in maintenance hemodialysis patients

Zhou Xi-yu1, Song Jie2, Zhang Xiao-dong2, Li Ying2, Li Hui2   

  1. 1Department of Nephrology, Shaanxi Municipal Corps Hospital of Chinese People’s Armed Police Forces, Xi’an  710054, Shaanxi Province, China
    2Department of Nephrology, Affiliated Hospital of Medical College of the Chinese People’s Armed Police Forces, Tianjin  300162, China
  • Received:2011-02-12 Revised:2011-04-11 Online:2011-05-21 Published:2011-05-21
  • Contact: Zhang Xiao-dong, Master, Attending physician, Department of Nephrology, Affiliated Hospital of Medical College of the Chinese People’s Armed Police Forces, Tianjin 300162, China LIHUI2009WUJING@163.com
  • About author:Zhou Xi-yu, Attending physician, Department of Nephrology, Shaanxi Municipal Corps Hospital of Chinese People’s Armed Police Forces, Xi’an 710054, Shaanxi Province, China zxiyu@sohu.com
  • Supported by:

    the Natural Science Foundation of Tianjin, No. 09JCYBJC09900*

PDF

624

被引次数

28

摘要：

背景：研究发现维持性血液透析的尿毒症患者体内存在“微炎症状态”。
目的：观察采用HA130型树脂灌流器行血液灌流对维持性血液透析患者微炎症的影响。
方法：选取维持性血液透析治疗的尿毒症患者60例，随机分为2组，灌流组采用HA130型树脂灌流器串联血液透析器进行血液灌流加血液透析治疗；透析组行单纯血液透析治疗。采集治疗前后两组患者的血清，检测高敏C-反应蛋白、肿瘤坏死因子α和白细胞介素6水平。
结果与结论：灌流组血清高敏C-反应蛋白、白细胞介素6和肿瘤坏死因子α水平治疗后较治疗前显著降低(P < 0.05)；透析组治疗后上述指标较治疗前略升高，差异无显著性意义。提示血液灌流可以降低维持性血液透析患者血清高敏C-反应蛋白、白细胞介素6和肿瘤坏死因子α水平，有利于减轻其微炎症反应。

关键词: 微炎症, HA130型树脂灌流器, 维持性血液透析, 血液灌流, 高敏C-反应蛋白, 白细胞介素6, 肿瘤坏死因子&alpha

Abstract:

BACKGROUND: Studies have found that the microinflammatory state exists in uremic patients undergoing maintenance hemodialysis (MHD).
OBJECTIVE: To investigate the effects of hemoperfusion using HA130 resin hemoperfusion apparatus on microinflammatory state in MHD patients.
METHODS: Sixty uremia patients undergoing maintenance hemodialysis were divided into two groups: hemoperfusion group (n=30) and MHD group (n=30). Hemoperfusion group underwent the treatment of hemoperfusion using HA130 resin hemoperfusion apparatus combined with hemodialysis. MHD group underwent the treatment of hemodialysis. The serum levels of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL–6) and tumor necrosis factor alpha (TNF-α) of all patients in the two group were detected before and after the treatment.
RESULTS AND CONCLUSION: In the hemoperfusion group, the serum levels of hs-CRP, IL-6 and TNF-α were lower after treatment than those before treatment, and the difference was significant (P < 0.05); In the MHD group, the serum levels of hs-CRP, IL-6 and TNF-α were higher after treatment than those before treatment, and the difference was not significant (P > 0.05). The results indicate that hemoperfusion using HA130 resin hemoperfusion apparatus can reduce the serum levels of hs-CRP, IL-6 and TNF-α and control the microinflammatory state in MHD patients.

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