中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (20): 3771-3774.doi: 10.3969/j.issn.1673-8225.2011.20.039

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

创面愈合与瘦素促进的跨膜信号途径

巫国辉，李小林，刘怡珍   

  1. 江西省人民医院整形颌面外科，江西省南昌市，330006
  • 收稿日期:2010-12-03 修回日期:2011-03-12 出版日期:2011-05-14 发布日期:2011-05-14
  • 作者简介:巫国辉★，男，1976年生，江西省丰城市人，汉族，2002年江西医学院毕业，硕士，副主任医师，硕士生导师。 wu_gh@163. com
  • 基金资助:

    课题受江西省科技支撑计划(2008-054，2009ZDS15900)和江西省卫生厅科技计划(20083016)资助。

Transmembrane signal transduction pathway of leptin effects on wound healing

Wu Guo-hui, Li Xiao-lin, Liu Yi-zheng   

  1. Department of Plastic and Maxillofacial Surgery, Jiangxi Province People’s Hospital, Nanchang  330006, Jiangxi Province, China
  • Received:2010-12-03 Revised:2011-03-12 Online:2011-05-14 Published:2011-05-14
  • About author:Wu Guo-hui★, Master, Associate chief physician, Master’s supervisor, Department of Plastic and Maxillofacial Surgery, Jiangxi Province People’s Hospital, Nanchang 330006, Jiangxi Province, China wu_gh@163.com
  • Supported by:

    the Science and Technology Support Project of Jiangxi Province, No. 2008-054*, 2009ZDS15900*; Science and Technology Program of Jiangxi Provincial Health Committee, No. 20083016*

PDF

322

被引次数

2

摘要：

背景：瘦素与其受体结合时，能以内分泌和旁分泌等方式促进新血管生成，调节炎症及免疫功能。
目的：探讨瘦素在创面愈合中的作用及跨膜信号传导机制。
方法：采用计算机检索CNKI数据库和PubMed数据库，以“瘦素，创面愈合，跨膜信号传导”和“leptin，wound healing，transmembrane singal”为关键词，语言设定为中文或英文。从瘦素在创面愈合的作用及跨膜信号传导2个方面进行总结。
结果与讨论：共检索到78篇文章，按纳入和排除标准对文献进行筛选，共纳入22篇文章。结果表明瘦素能够促进表皮角质形成细胞增殖、迁移，其跨膜信号传导涉及到JAK2，STST3，ERK1等多个信号分子。瘦素-受体信号的激活则改善创面愈合，其与瘦素促进表皮角质形成细胞增殖和再上皮化有关。

关键词: 瘦素, 创面愈合, 跨膜信号传导, 表皮角质形成细胞, 组织构建

Abstract:

BACKGROUND: When combined with its receptor, leptin can promote angiogenesis; modulate inflammation and immune function by means of endocrine, paracrine and other ways.
OBJECTIVE: To discuss and summarize the effect of leptin on wound healing and the mechanism of leptin transmembrane signal transduction.
METHODS: A computer retrieval of CNKI and PubMed databases was performed by using “leptin, wound healing, transmembrane signal” as key words in Chinese and English.
RESULTS AND DISCUSSION: Totally 78 articles were retrieved. According to inclusion and exclusion criteria, 22 articles were included after screening. The results showed that leptin plays an important role in wound healing, and it can promote the proliferation and migration of epidermal keratinocytes. We also found that JAK2, STST3, ERK1, and other signal molecules are involved in the transmembrane signal transduction of leptin.

中图分类号: