Homing time window of allogeneic bone marrow stem cells transplanted into Chinese miniature pigs with myocardial infarction

doi:10.3969/j.issn.2095-4344.2015.10.014

Abstract

Abstract:

BACKGROUND: Due to the different transplantation time after myocardial infarction, the homing ability of bone marrow mesenchymal stem cells to damaged tissues as well as the repairing role will be very different.

OBJECTIVE: To explore the optimal window time for the homing of bone marrow mesenchymal stem cells to the myocardial tissue after myocardial infarction.

METHODS: Eighteen Chinese miniature pigs were modeled by the ligation of left anterior descending coronary artery. BrdU-labeled bone marrow mesenchymal stem cells were injected via the coronary artery at 1 day, 3 days, 1 week, 2 weeks, 3 weeks, 4 weeks after modeling, respectively. Then, the animals were killed at 3 days after cell transplantation to detect the home of bone marrow mesenchymal stem cells in the infarct zone.

RESULTS AND CONCLUSION: BrdU-labeled positive cells with brown nuclei were visible at 1 day, 3 days, 1 week, 2 weeks, 3 weeks, and 4 weeks after myocardial infarction, especially at 1 week after myocardial infarction (P < 0.05). It indicates that the best homing window for bone marrow mesenchymal stem cells was at week after myocardial infarction, when the stem cell transplantation is given to be able to promote myocardial repair.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

全文链接：

Key words: Bone Marrow, Mesenchymal Stem Cell Transplantation, Myocardial Infarction

CLC Number:

R394.2

Xiang Li-ping, Guan Li-na, Shi Qi, Mu Yu-ming. Homing time window of allogeneic bone marrow stem cells transplanted into Chinese miniature pigs with myocardial infarction[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(10): 1551-1555.

Figures/Tables 5

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