Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (21): 3851-3854.doi: 10.3969/j.issn.1673-8225.2012.21.012

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Design of a biomimetic nanoscaled spinal cage by using computed tomography based three-dimensional construction

Guo Hong-gang1, Liu Jing2, Li Feng-tan1, Yang Shao-guang3, Chen Zhi4, Yao Fang-lian5, Dai Feng-ying6, Liu Wen-guang6   

  1. 1Department of Orthopedics, General Hospital of Tianjin Medical University, Tianjin  300052, China; 2Central Obstetrics and Gynecology Hospital of Tianjin, Tianjin   300052, China; 3Institute of Hematology, Chinese Academy of Medical Sciences, Tianjin   300052, China; 4Precision School of Tianjin University, Tianjin   300072, China; 5School of Chemical Technology, Tianjin University, Tianjin   300072, China;      6School of Materials Science and Engineering, Tianjin University, Tianjin   300072, China
  • Received:2011-10-15 Revised:2011-12-17 Online:2012-05-20 Published:2012-05-20
  • About author:Guo Hong-gang☆, Doctor, Associate professor, Master’s supervisor, Department of Orthopedics, General Hospital of Tianjin Medical University, Tianjin 300052, China honggangguo2000@yahoo.com.cn
  • Supported by:

     the National Natural Science Foundation of China, No. 81041061*; Science and Technology Foundation of Tianjin Education Commission, No. 20090125*

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Abstract:

BACKGROUND: The surface characteristics of nanoscaled spinal cage are the key factors to restrict the long-term clinical efficacy. The key step to develop the nanoscaled spinal cage is how to optimize the biological activity and structural features of the biodegradable cage to meet the cell growth.
OBJECTIVE: To analyze the feasibility of digital imaging and surface-modification in developing the spinal cage and to evaluate the method to construct the scaffold. 
METHODS: The morphology of the scaffold was obtained by analyzing anatomic data from digital scanning in spinal area; the biomimetic nanoscaled spinal cage was made with combination of β-tricalcium phosphate/chitosan/polycarpolactone via Nd: YAG with RGD modification. Morphology of the scaffold was observed, and its compatibility, hydrophilicity and degradation and biomechanic characteristics were observed at different periods.
RESULTS AND CONCLUSION: The three-dimensional construction of imaging could improve the fabrication accuracy of outer morphology for the scaffold, and it could reduce the parameter error during the simple physical and chemical preparation process which made the physical layout of the scaffold was remarkably arranged. As a satisfactory candidate for the spinal cage, Nd: YAG plus RGD surfaced modified scaffold showed more stable chemophysical characteristics and excellent affinity, and can meet the mechanical requirements of cage scaffolds. It has a good biocompatibility and has been regarded as an ideal candidate material for spinal cages.
 

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