Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (16): 2905-2908.doi: 10.3969/j.issn.1673-8225.2012.16.013

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Construction of a weaving tubular scaffold and its drug loading property

Zhang Wan-ling1, 2, Chen Nan-liang1, 2, Zhao Jiong-xin3, Zhang Xiu-fang1, Wang Da-xin4   

  1. 1College of Textiles, Donghua University, Shanghai  201620, China; 2Engineering Research Center of Technical Textile, Ministry of Education, Shanghai  201620, China; 3College of Materials Science and Engineering, Donghua University, Shanghai  201620, China; 4Institute of Biomedical Engineering, Yangzhou University, Yangzhou  225009, Jiangsu Province, China
  • Received:2011-03-05 Revised:2011-12-11 Online:2012-04-15 Published:2012-04-15
  • Contact: author: Chen Nan-liang, Doctor, Professor, College of Textiles, Donghua University, Shanghai 201620, China; Engineering Research Center of Technical Textile, Ministry of Education, Shanghai 201620, China nlch@dhu.edu.cn
  • About author:Zhang Wan-ling★, Studying for master’s degree, College of Textiles, Donghua University, Shanghai 201620, China; Engineering Research Center of Technical Textile, Ministry of Education, Shanghai 201620, China zhangwanling521@ mail.dhu.edu.cn

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Abstract:

BACKGROUND: Tubular scaffolds constructed using metal materials and general polymer materials have poor biocompatibility and drug loading property. Tubular scaffolds constructed using biodegradable polymer materials have good biocompatibility; besides, their double layer structure is good for the improvement of the radial support and drug loading property.
OBJECTIVE: To expound a construction method of a weaving double-layer composite tubular scaffold using biodegradable polymer materials as well as to explore the effects of the manufacturing materials and weaving structure on the drug loading property of the tubular scaffold.
METHODS: The lining tubular scaffold was weaved using poly (p-dioxanone), while the outer tubular scaffold was weaved using poly (glycolide-co-lactide). The change in quality of the tubular scaffold from before to after drug loading was detected using paclitaxel and azithromycin.
RESULTS AND CONCLUSION: The drug loading rate of the single-storey tubular scaffold weaved using poly (glycolide-co- lactide) was higher than that of the single-storey tubular scaffold weaved using poly (p-dioxanone). The drug loading rate of the two-storey composite tubular scaffold weaved using poly (glycolide-co-lactide) and poly (p-dioxanone) was superior to that of the single-storey tubular scaffold.

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