Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (16): 2861-2864.doi: 10.3969/j.issn.1673-8225.2012.16.003

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Effect of titanium surface micromorphology on osteoblasts growth and beta1 integrin expression

Xiao Zhen1, Li Jia-yi1, Meng Xiang-cai2, Wang Jing2, Li De-chao1   

  1. 1School of Stomatology, Jiamusi University, Jiamusi  154004, Heilongjiang Province, China; 2Jiamusi University, Jiamusi  154007, Heilongjiang Province, China
  • Received:2011-10-01 Revised:2011-10-19 Online:2012-04-15 Published:2012-04-15
  • Contact: author: Li De-chao, Doctor, Associate professor, School of Stomatology, Jiamusi University, Jiamusi 154004, Heilongjiang Province, China
  • About author:Xiao Zhen★, Studying for master’s degree, Physician, School of Stomatology, Jiamusi University, Jiamusi 154004, Heilongjiang Province, China xzloveljy1985@ 163.com

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Abstract:

BACKGROUND: Currently, micro-arc oxidation and gradually heat treatment are two common surface modification methods of chemical composition for titanium implant surfaces.
OBJECTIVE: To study the effect of titanium surface micromorphology on growth of osteoblasts.
METHODS: Primary cultured mouse osteoblasts were co-cultured with titanium plates with different surface treatments: titanium group, micro-arc oxidation group, alkali heat treatment group and micro-arc oxidation/alkali heat treatment group.
RESULTS AND CONCLUSION: The cells attached to the surfaces in the micro-arc oxidation/alkali heat treatment group were flat polygons and had better stretch. Expression of β1 integrin in osteoblasts micro-arc oxidation/alkali heat treatment group was stronger than those of the other groups (P < 0.05). The micro-arc oxidation combined with alkali heat treatment is more advantageous for the osteoblasts adhesion and expression of β1 integrin.

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