Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (16): 2851-2855.doi: 10.3969/j.issn.1673-8225.2012.16.001

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Application of tissue-engineered bone with osteoinductive calcium phosphate ceramic scaffold for mandible boxlike bone defect repair

Yao Jin-feng1, Li Xiao-yu2, Liang Zhi-gang1, Liang Rui1, Bao Chong-yun3, Chen Zhi-qing3   

  1. 1Department of Stomatology, Second People’s Hospital of Shenzhen, Shenzhen  518035, Guangdong Province, China; 2Department of Oral and Maxillofacial Surgery, People’s Hospital of Baoan, Shenzhen  518101, Guangdong Province, China; 3State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu  610041, Sichuan Province, China
  • Received:2011-08-11 Revised:2011-09-28 Online:2012-04-15 Published:2012-04-15
  • Contact: author: Liang Rui, Chief physician, Department of Stomatology, Second People’s Hospital of Shenzhen, Shenzhen 518035, Guangdong Province, China
  • About author:Yao Jin-feng☆, Doctor, Attending physician, Department of Stomatology, Second People’s Hospital of Shenzhen, Shenzhen 518035, Guangdong Province, China jinfeng-yao@ 163.com
  • Supported by:

     the National Natural Science Foundation of China, No. 30672337*

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Abstract:

BACKGROUND: Intrinsic osteoinductive biomaterials with no external growth factors or cells to build bone graft in non-bone parts is consider as in vivo bone tissue engineering which has feasible prospects in repair boxlike and segmental bone defect.
OBJECTIVE: To investigate the feasibility of using in vivo tissue engineered (TE) bone with osteoinductive calcium phosphate (Ca-P) ceramic to repair boxlike mandibular defect.
METHODS: The TE bone graft was constructed in vivo by implanting osteoinductive Ca-P ceramics in the femoral muscles of dog for 8 weeks, at the same period, 2 middle arch teeth in dog mandible from the right and left sides were removed for the formation of no teeth area with 20 mm. After 8 weeks, boxlike bone defect were created in two side of no teeth area and the TE bone graft in the femoral muscles was removed, then was transplanted to repair the defect, while in the opposite side of the mandibular defect was transplanted with the construction not in vivo as control.
RESULTS AND CONCLUSION: Mechanical of in vivo tissue-engineered bone grafts constructed in the femoral muscles was improved than simple Ca-P ceramic. Nuclear absorption intensity in mandibular defect area in was stronger than that in control area. Mandibular defect area had many bone tissues ingrowth. There were significant differences of bone area between mandibular defect area and control area. Therefore, it is feasible to construct a live bone graft of osteoinductive Ca-P ceramics in vivo which have obvious advantages of the mechanical and significant biological repair effect to repair a mandibular bone defect as compared with simple calcium phosphate ceramic substitute materials.

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