Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (15): 2848-2850.doi: 10.3969/j.issn.1673-8225.2012.15.041

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Blood brain barrier injury in animal models after cerebral ischemia-reperfusion 

Zhang Yu-ling, Cai Wen-jie   

  1. College of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai  200093, China
  • Received:2011-09-27 Revised:2011-11-22 Online:2012-04-08 Published:2012-04-08
  • About author:Zhang Yu-ling☆, Studying for doctorate, Laboratory technician, College of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China zhangyuling1982@hotmail.com
  • Supported by:

     the Special Science and Technology Research Foundation for Excellent Young Teachers in Shanghai Universities, No. slg07032*

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Abstract:

BACKGROUND: Cerebral ischemia-reperfusion results in the breakdown on blood brain barrier, leading to cerebral hemorrhage, brain edema and the aggravated damage of brain tissue.
OBJECTIVE: To summarize and analyze the effects of associated molecules on the blood-brain barrier damage in animal models after cerebral ischemia-reperfusion.
METHODS: A computer-based online search of PubMed (2001-01/2011-12) and CNKI (2006-01/2011-12) was performed for related articles with the keywords of “cerebral ischemia-reperfusion injury, blood brain barrier permeability” in English and Chinese, respectively. Researches on cerebral ischemia-reperfusion injury and blood brain barrier permeability were included. Repetitive studies were excluded. A total of 17 articles were retained.
RESULTS AND CONCLUSION: The molecules associated with blood brain barrier after cerebral ischemia-reperfusion injury were summarized from many aspects, such as inflammatory infiltration, matrix metalloproteinases hydrolysis and aquaporin opening. The blood-brain barrier function is regulated by many factors and many links. The 3-hour time window of the blood brain barrier opening after cerebral ischemia-reperfusion injury is crucial for the emergency treatment of ischemic penumbra. The later repairing effect of matrix metalloproteinase may provide basis for the drug innovation.

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