Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (15): 2709-2714.doi: 10.3969/j.issn.1673-8225.2012.15.011

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Expression of heat shock protein 90 and inhibitor of apoptosis protein Livin in pathologic scars

Wang Da-wei1, 2, Wang Xi-mei1, Liu Lin-bo1, Wang Qi-ying1, Peng Qian1, Zhang Juan1, 2, Sun Yu-feng1, 2, Zhang Qiong-ge1, 2   

  1. 1Department of Plastic Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou  450052, Henan Province, China; 2Key-Disciplines Laboratory Clinical-Medicine Henan, Zhengzhou  450052, Henan Province, China
  • Received:2011-10-10 Revised:2011-11-24 Online:2012-04-08 Published:2012-04-08
  • Contact: author: Wang Xi-mei, Doctor, Professor, Chief physician, Master’s supervisor, Department of Plastic Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
  • About author:Wang Da-wei★, Studying for master’s degree, Department of Plastic Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China; Key-disciplines Laboratory Clinical-Medicine Henan, Zhengzhou 450052, Henan Province, China wdw901@yahoo.com.cn

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Abstract:

BACKGROUND: In recent years, related research has shown that heat shock protein 90 (HSP90) and inhibitor of apoptosis protein Livin play a very important role in the process of cell apoptosis. However, the roles of HSP90 and Livin in the formation of pathologic scars are rarely reported.
OBJECTIVE: To investigate the expression and correlation of HSP90 and Livin in pathologic scars in gene and protein levels.
METHODS: Reverse transcription-PCR and SP immunohistochemical methods were used to detect the expressions of HSP90 and Livin in 24 cases of keloid, 26 cases of hypertrophic scar, 22 cases of non-pathologic scar and 20 cases of normal skin tissue.
RESULTS AND CONCLUSION: The positive levels of HSP90 and Livin in the keloid group and hypertrophic scar group were higher than that in the non-pathologic scar group and normal skin group (P < 0.05). There was a positive correlation between HSP90 and Livin expressions in the pathologic scars (rs=0.436, P < 0.05). RT-PCR results were similar to the immunohistochemical results. The results suggest that HSP90 and Livin may play an important role in the formation of pathologic scar; and there may be a synergistic effect between the two.
Wang DW, Wang XM, Liu LB, Wang QY, Peng Q, Zhang J, Sun YF, Zhang QG. Expression of heat shock protein 90 and inhibitor of apoptosis protein Livin in pathologic scars. Zhongguo Zuzhi Gongcheng Yanjiu. 2012;16(15): 2709-2714.     [http://www.crter.cn  http://en.zglckf.com]

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