The treatment of wounds caused by rejection after allogeneic bone transplantation: traditional wound dressing and vacuum sealing drainage

doi:10.3969/j.issn.2095-4344.2014.18.025

Abstract

Abstract:

BACKGROUND: In the treatment of wound sustained exudate caused by rejection after allogeneic bone transplantation, traditional method of wound dressing not only needs frequent dressing changes, but also can not completely close the wound.
OBJECTIVE: To compare the effect of traditional method and vacuum sealing drainage in the treatment of wound sustained exudate caused by rejection after allograft bone transplantation.
METHODS: A total of 45 patients who developed wound sustained exudates caused by rejection after allogeneic bone transplantation, were randomly divided into test and control groups according to the wishes of patients. The test group included 27 patients who were treated with vacuum sealing drainage, and the control group included 18 patients who were treated with conventional dressing. Number of dressings, wound healing time and infection rates were detected and compared in the two groups.
RESULTS AND CONCLUSION: In the test group the average number of dressings was 1.22, the wound average healing time were 16.26 days, infection rates were 4%. In the control group the average number of dressings was 9.78, the wound average healing time were 21.06 days, infection rates were 28%. There were significant differences in the wound healing time, the number of dressings and infection rates between the two groups (P < 0.05). The vacuum sealing drainage can shorten wound healing time, reduce the number of dressings, and lower infection rates. Vacuum sealing drainage is an effective method for the treatment of wound sustained exudates caused by rejection after allograft bone transplantation.

中国组织工程研究杂志出版内容重点：肾移植；肝移植；移植；心脏移植；组织移植；皮肤移植；皮瓣移植；血管移植；器官移植；组织工程

全文链接：

Key words: biocompatible materials, drainage, wound infection, rejection

CLC Number:

R318

Zhang Nu, Zhang Chun, Liu Shi-qing. The treatment of wounds caused by rejection after allogeneic bone transplantation: traditional wound dressing and vacuum sealing drainage[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(18): 2933-2938.

Figures/Tables 3

2.3 基线资料比较两组性别比例、年龄、术后排斥反应出现的时间及持续时间等基线资料比较差异无显著性意义，具有可比性。 2.4 两组治疗效果比较两组患者在同种异体骨移植后7-14 d出现排斥反应，表现为伤口渗液，渗出淡红色清亮液体，伤口周围无红肿，无压痛，皮温不高，全身无发热，渗出液涂片未发现脓球，细菌培养无细菌生长。两组均行抗生素预防感染及口服醋酸泼尼松治疗。试验组27例患者应用负压封闭引流治疗，由于排斥反应延续时间一般为5-7 d，故22例使用负压封闭引流1次后伤口愈合，4例由于排斥反应延续时间较长，故在7 d后更换负压封闭引流，1例患者出现发热，患肢肿痛加剧，闻到异味，看到泡沫内出现黄绿色、灰褐色等污点，考虑为感染，遂拆除负压封闭引流，伤口分泌物作涂片及细菌培养，伤口行清创去除同种异体骨和内固定材料，改为持续灌注冲洗引流，期间行传统换药2次，伤口愈合。总之试验组平均换药次数为1.22次，伤口平均愈合时间为16.26 d，伤口感染率为4%，取得了较好的治疗效果。对照组18例应用传统换药治疗，根据伤口渗液量，每日换药更换无菌敷料一二次，渗液量减少后改为隔日换药1次，每次换药尽量挤出伤口内的积液，一般7-14 d后伤口愈合，伤口平均愈合时间为21.06 d，其中有5例出现了伤口感染，感染率为28%，表现为患者出现发热，患肢肿痛加剧，伤口分泌物黏稠，黄绿色，闻到异味，遂行伤口清创去除同种异体骨，改为持续灌注冲洗引流治疗后伤口愈合。比较两组间伤口换药次数、愈合时间及伤口感染率数据差异均有显著性意义，见表1-3，试验组较对照组创面愈合时间明显缩短，换药次数明显减少，极大地减轻了临床医生的工作强度。"

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