Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (12): 2277-2280.doi: 10.3969/j.issn.1673-8225.2012.12.044

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Effect of vitapex on bone regeneration following refractory periapical periodontitis  

Jin Hui, Wang Xiu-mei, Ge Ya-na, Zhang Cheng-ren, Zhu Lan-lan, Xu Ye   

  1. Department of Oral Medicine, Second Affiliated Hospital of Harbin Medical University, Harbin  150081, Heilongjiang Province, China
  • Received:2011-09-28 Revised:2012-02-09 Online:2012-03-18 Published:2012-03-18
  • Contact: author: Wang Xiu-mei, Chief physician, Professor, Master’s supervisor, Department of Oral Medicine, Second Affiliated Hospital of Harbin Medical University, Harbin 150081, Heilongjiang Province, China hrbwangmei@ yahoo.com.cn
  • About author:Jin Hui★, Studying for master’s degree, Department of Oral Medicine, Second Affiliated Hospital of Harbin Medical University, Harbin 150081, Heilongjiang Province, China huistrive@163.com
  • Supported by:

    the Postdoctoral Startup Foundation of Heilongjiang Government, No. LRB05-279*; the Natural Science Foundation of Heilongjiang Province, No. D201175*

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Abstract:

BACKGROUND: Conventional root canal treatment for periapical periodontitis with periapical cementoclasia has poor efficacy.
OBJECTIVE: To observe the effect of vitapex on bone regeneration beyond the apical foramen.
METHODS: 120 patients with periapical periodontitis of the permanent teeth whose area of bone destruction was ≥2 mm were selected, and they were randomly divided into two groups: the zinc oxide group was treated with conventional root canal therpy, and the vitapex group was treated with vitapex beyond the apical foramen to fill bone destruction area. All the patients were required of regular referral. Then, deposition of new bone in bone destruction area was identified by using X-ray examination. At last, surplus vitapex paste was removed and permanent filling was conducted.
RESULTS AND CONCLUSION: After 1-year referral, 43 incisors and 17 molars of the zinc oxide group were successful in 30 and 11 cases, respectively; 38 incisors and 22 molars of the vitapex group succeeded in 36 and 20 cases, respectively. The difference between the two groups was significant (P < 0.05). And vitapex is worthy of clinical application.
 

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