Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (9): 1696-1700.doi: 10.3969/j.issn.1673-8225.2012.09.040

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Effects of local delivery antibiotics on cells in site

Cao Zheng, Hou Shu-xun   

  1. Department of Orthopedics, First Affiliated Hospital of Liberation Army General Hospital, Beijing  100037, China
  • Received:2011-09-16 Revised:2011-10-26 Online:2012-02-26 Published:2012-02-26
  • Contact: Hou Shu-xun, Master, Chief physician, Doctoral supervisor, Department of Orthopedics, First Affiliated Hospital of Liberation Army General Hospital, Beijing 100037, China hsxortho@hotmail.com
  • About author:Cao Zheng☆, Studying for doctorate, Physician, Department of Orthopedics, First Affiliated Hospital of Liberation Army General Hospital, Beijing 100037, China caozheng_81@163.com

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Abstract:

BACKGROUND: Local antibiotic delivery can achieve adequate local antibiotic levels and low serum concentrations for the treatment of bone and soft tissue infections. However, the toxic effects of high local antibiotic concentrations on local cells may affect the progress of healing.
OBJECTIVE: To understand the effects of antibiotics on local cells, and find a method to reduce the adverse effects of local antibiotics.
METHODS: PubMed database and Chinese Biomedical Literature Database (CBM) were searched for articles with the effects of antibiotics on orthopedics local cells published between 1990 and 2011. Totally 40 representative articles were selected to analyze the effects of antibiotics on local cells.
RESULTS AND CONCLUSION: At high antibiotic concentrations, most of antibiotics inhibited the survival, proliferation, metabolism and differentiation of cells. While in some conditions, few antibiotics enhance the proliferation, function and differentiation of some cells at special dosage. The effect depended on the kinds of antibiotics and cells. And the drug-induced cells alterations were reversible. The side effects of antibiotics could be overcome by bone morphogenetic protein and preventing the pH from decreasing in traumatized areas. The effects of local delivery antibiotics on cells in site can help to reduce side effect in the treatment of infection by the selection of appropriate kind and dosage of antibiotics. Further studies are needed to optimize local antibiotic delivery.

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