Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (9): 1573-1576.doi: 10.3969/j.issn.1673-8225.2012.09.013

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Effect of topical application of alendronate on implant osseointegration in non-load period:     A X-ray observation

Ji Lin-lin1, Liu Zhong-hao2, Zhou Wen-juan2, Xu Sheng2   

  1. 1Graduate School of Binzhou Medical College, Yantai  264003, Shandong Province, China; 2Stomatological Hospital of Yantai, Yantai  264008, Shandong Province, China
  • Received:2011-11-30 Revised:2011-12-10 Online:2012-02-26 Published:2012-02-26
  • Contact: Liu Zhong-hao, Associate chief physician, Master’s supervisor, Stomatological Hospital of Yantai, Yantai 264008, Shandong Province, China dentlzh@163.com
  • About author:Ji Lin-lin★, Studying for master’s degree, Graduate School of Binzhou Medical College, Yantai 264003, Shandong Province, China dichenji007@163.com
  • Supported by:

    the Natural Science Foundation Project of Shandong Province, No. Y2008C43*

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Abstract:

BACKGROUND: As the third-generation of bisphosphonates, alendronate has a strong ability in inhibiting bone resorption.
OBJECTIVE: To study the effect of alendronate on non-load period bone around the implants.
METHODS: Six healthy adult Beagle dogs were randomly divided into experimental and control groups. The second and fourth premolar totally 24 tooth positions in bilateral mandibular from each dog were treated with immediate implant surgery at 1, 29, 43 and 50 days. Alendronate was local injected around the implant twice a week in the experimental group, but in the control group alendronate was instead by normal saline.
RESULTS AND CONCLUSION: X-ray film showed that implant osseointegration was in good condition at 57 days, and the formation of trabecular bone at 2 weeks around the implant in the experimental group was significantly earlier than that in the control group. It is indicated that alendronate can promote the early formation of trabecular, thus affecting the bone remodeling to increase the osseointegration at non-load period around the implants.

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