Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (8): 1377-1381.doi: 10.3969/j.issn.1673-8225.2012.08.011

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Property research of electrospun polyester/poly(L-lactic acid) small diameter vascular graft  

Du Xue-zi1, Li Yu-ling1, Chen Zhi-long2, Yan Yi-jia2   

  1. 1Key Laboratory of Textile Science & Technology, Ministry of Education, College of Textile Engineering, Donghua University, Shanghai  201620, China; 2School of Chemical Engineering and Bioengineering, Donghua University, Shanghai  201620, China
  • Received:2011-07-19 Revised:2011-08-17 Online:2012-02-19 Published:2012-02-19
  • Contact: Li Yu-ling, Doctor, Professor, Key Laboratory of Textile Science & Technology, Ministry of Education, College of Textile Engineering, Donghua University, Shanghai 201620, China lylu@dhu.edu.cn
  • About author:Du Xue-zi★, Studying for master’s degree, Key Laboratory of Textile Science & Technology, Ministry of Education, College of Textile Engineering, Donghua University, Shanghai 201620, China duxuezi@ yahoo.com.cn
  • Supported by:

    the National “111” Project of China, No. B07024*

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Abstract:

BACKGROUND: At present, poly(L-lactic acid) (PLLA) is always used as the biological material of vascular graft. However, decomposition rate of PLLA in the body cannot match with cells growing rate of the diseased small blood vessel, and absolute mechanical strength of PLLA is not quite high, which cannot meet the requirements of the diseased blood vessel.
OBJECTIVE: To explore the biomechanical performance and biocompatibility of electrospun polyester/PLLA small diameter vascular grafts at different matching ratio.
METHODS: Small diameter vascular grafts were produced with polyester and PLLA in the mass ratio of 10:0, 7:3, 5:5, 3:7, 0:10, using double injection pumps in the opposite directions.
RESULTS AND CONCLUSION: In the nanoscale conditions, polyester and PLLA with mixed structure made by the injection pumps in the opposite directions could produce chemical reaction, maintaining their characteristics. Compared with pure PLLA, the mixed structure had greatly improved the mechanical performance with the high porosity and low water permeability that was good for the growth of cells, and could not lead to a liquid penetration. In the mixed conditions, the biocompatibility of the scaffold could be improved by adjusting the process parameters to refine fibers. The vascular graft (mass ratio 5:5) had full advantage of material properties.

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