Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (5): 903-906.doi: 10.3969/j.issn.1673-8225.2012.05.033

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Expression and distribution of regulatory T lymphocytes in liver transplant tissues

Nong Cun-li, Long Teng-he, Guo Qian   

  1. Fourth Affiliated Hospital of Guangxi Medical University (Liuzhou Worker’s Hospital), Liuzhou  545005, Guangxi Zhuang Autonomous Region, China
  • Received:2011-09-03 Revised:2011-12-05 Online:2012-01-29 Published:2012-01-29
  • Contact: Guo Qian, Chief physician, Fourth Affiliated Hospital of Guangxi Medical University (Liuzhou Worker’s Hospital), Liuzhou 545005, Guangxi Zhuang Autonomous Region, China prof.guoqian@yahoo.com.cn
  • About author:Nong Cun-li, Attending physician, Fourth Affiliated Hospital of Guangxi Medical University (Liuzhou Worker’s Hospital), Liuzhou 545005, Guangxi Zhuang Autonomous Region, China non.cunlli@yahoo.com.cn

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Abstract:

BACKGROUND: Regulatory T cells play an important role in the immune tolerance induction of liver transplantation in animals.
OBJECTIVE: To explore the expression and distribution of regulatory T cells in the liver transplantation tissues.
METHODS: An online search of Medline (1990-01/2010-12), Wanfang Med Online (1990-01/2010-12) and China Hospital Knowledge Database (1998-01/2010-12) was performed for the related articles with the key words of “liver transplantation, rejection immune tolerance, regulatory T cells” in English and in Chinese.
RESULTS AND CONCLUSION: Regulatory T lymphocytes are one of the major regulatory cells in the regulation of the immune response; they assist the humoral and cell-mediated immunity. Regulatory T lymphocytes and their cytokines play a very import role in the immunoreactions of liver transplantation: the balance of Th1/rh2 is closely related with the immunoreactions after liver transplantation; the increased secretion of Th1 cytokine causes liver transplant rejection. Immune tolerance reactions are more likely to occur when the Th1/rh2 balance shifts to Th2. Clinical evaluation of the immune status in liver transplantation patients should be combined with ImmuKnow, T lymphocytes, plasma concentration, liver function testing and other related inspection, therefore the individual use of immunosuppressive agents in liver transplant recipients can be effectively guided

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