Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (5): 859-862.doi: 10.3969/j.issn.1673-8225.2012.05.024

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Application of blood oxygen level-dependent magnetic resonance imaging in chronic kidney disease

Wang Wen-juan1, 2, Guo Yan1, Li Zhu-hao1, Cai Hua-song1, Shi Yao-ping1, Yang Dong1   

  1. 1Department of Radiology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou  510080, Guangdong Province, China; 2Weifang People’s Hospital, Weifang  261041, Shandong Province, China
  • Received:2011-08-08 Revised:2011-12-23 Online:2012-01-29 Published:2012-01-29
  • Contact: Guo Yan, Chief physician, Doctoral supervisor, Department of Radiology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China dr.guoyan@163.com
  • About author:Wang Wen-juan☆, Studying for doctorate, Attending physician, Department of Radiology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China; Weifang People’s Hospital, Weifang 261041, Shandong Province, China wangwj212@sina.com
  • Supported by:

    Guangdong Science and Technology Program, No.2010 B080701067*

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Abstract:

BACKGROUND: Blood oxygen level-dependent magnetic resonance imaging is a non-invasive method to monitor renal blood oxygen content.
OBJECTIVE: To explore the application of blood oxygen level-dependent magnetic resonance imaging in the evaluation of renal blood oxygen content and renal function.
METHODS: Blood oxygen level-dependent magnetic resonance imaging was used on 20 healthy volunteers and 24 chronic kidney disease patients. The cortical and medullary R2* value were measured and compared in each group.
RESULTS AND CONCLUSION: Normal medullary R2* value was higher than cortical R2* value (P < 0.05). There was no significant difference in bilateral kidney (P > 0.05). Patients with chronic kidney disease had higher cortical and medullary R2* than normal health (P < 0.05). There was a positive correlation between serum creatinine and renal R2* (r=0.564, P =0.004; r=0.588, P =0.003). This research shows that blood oxygen level-dependent magnetic resonance imaging can reflect renal blood oxygen levels, and has certain value in evaluate the renal function.

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