Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (5): 831-834.doi: 10.3969/j.issn.1673-8225.2012.05.017

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Massive bone allograft combined with autologous bone marrow transplantation for proximal femoral defects resulting from tumor resection 

Li Bo1, 2, Chen Jing3, Que Xiang-yong1, Chen Wen-yao1, Li Xin-zhi1   

  1. 1Department of Orthopedics, Renhe Hospital of Three Gorges University, Yichang  443001, Hubei Province, China; 2Department of Orthopedics, Changhang Hospital of Yichang, Yichang 443003, Hubei Province, China; 3Department of Morphology, Medical College of Three Gorges University, Yichang  443002, Hubei Province, China
  • Received:2011-11-17 Revised:2011-12-08 Online:2012-01-29 Published:2012-01-29
  • Contact: Li Xin-zhi, Doctor, Associate professor, Associate chief physician, Master’s supervisor, Department of Orthopedics, Renhe Hospital of Three Gorges University, Yichang 443001, Hubei Province, China lixpj@163.com
  • About author:Li Bo★, Master, Attending physician, Department of Orthopedics, Renhe Hospital of Three Gorges University, Yichang 443001, Hubei Province, China; Department of Orthopedics, Changhang Hospital of Yichang, Yichang 443003, Hubei Province, China libo1019@126.com

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Abstract:

BACKGROUND: Bone defects due to bone tumor resection are difficult problems in clinic, and how to repair bone defects is a hotspot in the orthopedics.
OBJECTIVE: To discuss the clinical application and effect of massive bone allograft combined with autologous bone marrow transplantation for the defects after proximal femoral tumor resection. 
METHODS: From July 2000 to June 2005, a total of 12 patients with massive bone defects after proximal femoral tumor resections received irradiated frozen massive bone allograft combined with autologous bone marrow transplantation. The surgery used “eggshell” technology similar to the spinal cord, femoral head was empty, the round ligament and cortical bone of the femoral head was kept, as well as one third blood supply of the femoral head. Massive bone allograft combined with autologous bone marrow transplantation and internal fixation was performed.
RESULTS AND CONCLUSION: Patients were followed-up regularly for 6-11 years after operation. The X-ray film showed that vascularization and bone trabeculae crossing the host bone could be seen in 12 cases. In addition, the mean MSTS93 score of 12 patients was 26.33, and the excellent rate of limb function was 83.3%. Massive bone allograft combined with autologous bone marrow transplantation is an effective method for proximal femoral defects resulting from tumor resection and can integrate with the surrounding host bone.

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