Abstract:

BACKGROUND: Organ transplant patients require lifelong use of immunosuppressive reagent, so a rational use of immunosuppressive agents is the key to organ transplantation.
OBJECTIVE: To summarize various representative drugs in organ transplantation and to propose a suitable immunosuppressive agent for organ transplant patients.
METHODS: The first author searched PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) and Wanfang Database (http://www.wanfangdata.com.cn) from 1999-01/2011-06. English key terms are “immunosuppressive drug, reject reaction, cyclosporine A, tacrolimus (FK506)”, and Chinese key terms are “immunosuppressive drugs, renal transplantation, liver transplantation, rejection”. A total of 105 documents were screened out, and those focusing on the application and clinical effectiveness of different immunosuppressive drugs in organ transplantation were included, while repeated experiments and old articles were excluded. Recently published articles or those published in the authority magazine were preferred in the same field, ultimately 20 literatures were involved in the final analysis.
RESULTS AND CONCLUSION: Common immunosuppressive drugs include the adrenal cortical hormone, metabolic antagonists, and T lymphocyte inhibitor. However, each immunosuppressant has certain toxic side effects when they are playing immunosuppressive effects, so side effects should be avoided. How to exhibit the synergic effect between the immunosuppressive drugs and to achieve the best clinical efficacy needs further attention. We should closely monitor blood concentration and give individual drug therapy, so as to lower incidence of toxic side effects.