Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (53): 10011-10015.doi: 10.3969/j.issn.1673-8225.2011.53.032

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Activity of nuclear factor-kappa B in peripheral blood mononuclear cells of diabetes patients at different levels of blood glucose control with maintenance hemodialysis

Wang Jing-fu1, Xing En-hong2, Duan Shu-zhong1, Zhang Kun1, Guo Feng-ling1, Zhao Ya-juan1, Hu Gui-cai1   

  1. 1Department of Nephrology, 2Central Laboratory, Affiliated Hospital of Chengde Medical College, Chengde  067000, Hebei Province, China
  • Received:2011-07-12 Revised:2011-09-01 Online:2011-12-31 Published:2011-12-31
  • About author:Wang Jing-fu★, Master, Associate chief physician, Department of Nephrology, Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province, China wangjingfu1968@ sina.com
  • Supported by:

    Scientific Technology Research and Development Program of Chengde City, No.201021051*

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Abstract:

BACKGROUND: Abnormal activation of nuclear factor-kappa B (NF-κB) and protein kinase C signal transduction pathway is the central link of occurrence and development of diabetes mellitus and related complications.
OBJECTIVE: To investigate the NF-κB activity in peripheral blood mononuclear cells (PBMC) in diabetes patients of different levels of blood glucose control with maintenance hemodialysis and investigate the relationship of NF-κB activity with glycosylated hemoglobin (HbAlc) and high sensitive C reactive protein (hs-CRP) levels and malnutrition.
METHODS: The indices of 71 chronic renal failure uremia patients with maintenance hemodialysis were analyzed through cross-sectional study. Twenty-two diabetic nephropathy patients with maintenance hemodialysis were divided into good control of blood glucose group (n=12) and poor control of blood glucose group (n=10). The other 49 non-diabetic nephropathy patients with maintenance hemodialysis were taken as control group.
RESULTS AND CONCLUSION: The serum albumin and serum prealbumin levels of patients in the poor control of blood glucose group were significantly lower than those in the good control of blood glucose group and non-diabetic nephropathy group.The serum hs-CRP level and NF-κB activity of patients in poor control of blood glucose group were significantly higher than those in the good control of blood glucose group and non-diabetic nephropathy group. HbAlc was positively correlated with serum hs-CRP level and NF-κB activity and was negatively correlated with serum albumin and serum prealbumin. NF-κB activity was positively correlated with hs-CRP levels and was negatively correlated with serum albumin and serum prealbumin. The results suggest that poorer control of blood glucose in diabetic nephropathy patients with maintenance hemodialysis leads to stronger NF-κB activity, more obvious inflammatory reaction and more severe malnutrition. Abnormal activation of NF-κB induced by poor control of blood glucose is one of the main reasons that aggravate inflammatory reaction and malnutrition for diabetes patients with maintenance hemodialysis.

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