Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (53): 9969-9972.doi: 10.3969/j.issn.1673-8225.2011.53.022

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Effect of tripterygium glycosides on pulmonary transplantation rejection of syngeneic rats

Piao Tie-hua1, Gu Yue2, Cai Hong-yan1, Xi Zhong-yuan1   

  1. 1First Department of Internal Medicine, Traditional Chinese Medicine Academy of Jilin, Changchun 130021, Jilin Province, China
    2Department of Respiratory Medicine, First Hospital of Jilin University, Changchun  130021, Jilin Province, China
  • Received:2011-08-15 Revised:2011-10-18 Online:2011-12-31 Published:2011-12-31
  • About author:Piao Tie-hua★, Master, Associate chief physician Medicine, First Department of Internal Medicine, Traditional Chinese Medicine Academy of Jilin, Changchun 130021, Jilin Province, China neurology@139.com

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Abstract:

BACKGROUND: Tripterygium wilfordii is woodiness lianas of celastraceae and has been proved to possess immunosuppression. Tripterygium wilfordii can be used as immunomodulator after lung transplantation.
OBJECTIVE: To study the inhibition of tripterygium glycosides against acute rejection after lung transplantation of rats and its effect on the intercellular adhesion molecule 1 (ICAM-1) level and the number of activated T cells in the peripheral blood.
METHODS: Fifty Sprague Dawley rats were selected randomly and divided into 3 groups: the blank group, the control group and the treatment group. Normal rats were the blank group. Lung orthotopic transplantation models were established by the modified “cuff-like” vessel anastomosis technique in the rats of the control group and the treatment group. After surgery, the blank group and the control group were irrigated the rat stomach with normal saline at 1 mL/d, while the treatment group was treated with tripterygium glycosides at 50 mg/kg/d for 5 days.
RESULTS AND CONCLUSION: The rejection grade of lung transplantation of the treatment group was significantly lower than that of the control group (P < 0.01); the number of CD25+T cells and the ICAM-1 level in the peripheral blood of the treatment group were higher compared with the blank group (P < 0.05), and lower than those of the control group (P < 0.05). Tripterygium glycosides may reduce the peripheral CD25+T cells and antagonize the ICAM-1 in lung tissues to inhibit the acute rejection after lung transplant in rats.

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