Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (51): 9553-9556.doi: 10.3969/j.issn.1673-8225.2011.51.013

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Cytocompatibility of magnesium alloys after surface fluoridation tested by human bone marrow mesenchymal cells

Jiang Hai-ying1, Yan Zheng-bin1, 2, Zhang Zhao3, Ai Hong-jun4   

  1. 1Department of Stomatology, Daqing Oilfield General Hospital, Daqing  163001, Heilongjiang Province, China
    2School of Stomatology, Jiamusi University, Jiamusi  154002, Heilongjiang Province, China
    3Medical Clinic of Guangzhou Sports Polytechnic College, Guangzhou  510650, Guangdong Province, China
    4Department of Prosthodontics, Affiliated Stomatological Hospital of China Medical University, Shenyang  110002, Liaoning Province, China
  • Received:2011-07-14 Revised:2011-11-08 Online:2011-12-17 Published:2011-12-17
  • Contact: Ai Hong-jun, Doctoral supervisor, Professor, Department of Prosthodontics, Affiliated Stomatological Hospital of China Medical University, Shenyang 110002, Liaoning Province, China
  • About author:Jiang Hai-ying★, Master, Attending physician, Department of Stomatology, Daqing Oilfield General Hospital, Daqing 163001, Heilongjiang Province, China wanghaoyu2002 @126.com
  • Supported by:

    Natural Science and Technology Foundation of Liaoning Province, No. 2008079*

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Abstract:

BACKGROUND: AZ31B magnesium alloy with surface flouridization is a new type of magnesium alloy developed by Institute of Metal Research, Chinese Academy of Sciences. Its biocompatibility is unclear. 
OBJECTIVE: To observe the cytocompatibility of magnesium alloys with surface fluoridation tested by human bone marrow mesenchymal cells (BMSCs).
METHODS: Human BMSCs were identified and cultured. The AZ31B magnesium alloy was taken as control and the AZ31B magnesium alloy with surface fluoridation was experimental group. Human BMSCs were the test cells. Leaching liquor of the alloy in both groups was used for cell compatibility experiments in vitro in order to evaluate the biocompatibility of AZ31B magnesium alloy.
RESULTS AND CONCLUSION: The cell survival rate of AZ31B magnesium alloys with surface fluoridation was significantly higher than AZ31B magnesium alloys without surface fluoridation. The toxicity of cells in the leaching liquor of AZ31B magnesium alloys with surface fluoridation was Grade 1 and was non-toxic to the basic cell growth. The biocompatibility of the AZ31B magnesium alloys with surface fluoridation is superior to the AZ31B magnesium alloys without surface fluoridation.

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