Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (49): 9235-9238.doi: 10.3969/j.issn.1673-8225.2011.49.027

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Three-month therapeutic effect of bone marrow mesenchymal stem cells transplantation on the treatment of X-linked muscular distrophy mice

Xu Yi-feng, Yang Xiao-feng, Wang Hong-mei, Zhang Yi-bin, Lü Nai-wu, Zhou Jin-xu   

  1. Cell Therapy Center, the 463 Hospital of Chinese PLA, Shenyang  110042, Liaoning Province, China
  • Received:2011-06-21 Revised:2011-10-31 Online:2011-12-03 Published:2011-12-03
  • Contact: Yang Xiao-feng, Master’s supervisor, Chief physician, Cell Therapy Center, the 463 Hospital of Chinese PLA, Shenyang 110042, Liaoning Province, China yxf463@yahoo.com.cn
  • About author:Xu Yi-feng★, Master, Attending pgysician, Cell Therapy Center, the 463 Hospital of Chinese PLA, Shenyang 110042, Liaoning Province, China xuyifeng2@yahoo.com.cn
  • Supported by:

    Major Research Project of Liaoning Province, No. 2008225009*

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Abstract:

BACKGROUND: Stem cells transplantation for treatment of X-limked muscular dystrophy (mdx) is the research hotspot. To compare with hematopoietic stem cells transplantation, mesenchymal stem cells transplantation has less risk.
OBJECTIVE: To study the effect of bone marrow mesenchymal stem cells transplantation on the treatment of Duchenne muscular distrophy (DMD) mice．
METHODS: Sixteen 4-week-old mdx mice were randomly divided into two groups: control group and transplanted group, eight mice in each group. C57BL/6 mice bone marrow mesenchymal stem cells or normal saline were injected intravenously and intramuscularly into the mice in transplanted group, respectively.
RESULTS AND CONCLUSION: Three months after transplantation, the serum creatine kinase in transplanted group was decreased obviously, and the expression of dystrophin protein could be seen on the skeletal muscle membrane. There was on expression of dystrophin protein in control group. There were no obvious changes of motor function in two groups. Bone marrow mesenchymal stem cells transplantation had some therapeutic effect on the treatment of mdx mice, it might reduce the damage of muscle cell membrane and delay the progression of the disease.

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