Methylprednisolone therapy for severe pulmonary infection after kidney transplantation

doi:10.3969/j.issn.2095-4344.2014.05.015

Abstract

Abstract:

BACKGROUND: Pulmonary infection is the main complication after kidney transplantation, and its onset and morbidity may be related to conventional oral drugs after kidney transplantation.

OBJECTIVE: To analyze the effect of methylprednisolone instead of prednisone on severe pulmonary infection after kidney transplantation.

METHODS: Clinical data of 58 patients with severe pulmonary infection after kidney transplantation were retrospectively analyzed. First, according to the characteristics of post-onset patients and lung CT findings, broad-spectrum antibiotics and anti-fungal treatment were adopted, and subsequently targeted therapy, that is, withdrawal or adjustment of dosage and combination regimen of immunosuppressive agents, was employed depending on etiology, fungi and virus detection results. Among the 58 patients, 28 patients were injected methylprednisolone, and 30 patients took oral prednisone. Hyoxemia correction, support therapy and immune replacement therapy were applied.

RESULTS AND CONCLUSION: Thirty-nine of 58 patients (67.2%) were positive for pathogens, including 7 cases of simple bacterial pneumonia, 4 cases of fungal pneumonia, 3 cases of simple cytomegalovirus infection, and 25 cases of mixed infections (5 cases of multiple bacterial infections, 17 cases of fungal and bacterial co-infections, and 3 cases of fungi, bacteria and cytomegalovirus co-infections). Patients subjected to methylprednisolone treatment spent shorter time to recover their temperature than those undergoing oral prednisone (P < 0.05). In addition, creatinine fluctuation range in the methylprednisolone group was less than that in the prednisone group (P < 0.05). The results showed that intravenous injection of methylprednisolone may accelerate absorption of inflammatory exudate in the lung and shorten treatment time.

中国组织工程研究杂志出版内容重点：肾移植；肝移植；移植；心脏移植；组织移植；皮肤移植；皮瓣移植；血管移植；器官移植；组织工程

全文链接：

Key words: organ transplantation, kidney transplantation, pneumonia, methylprednisolone, blood gas analysis

CLC Number:

R318

Wei Xing, Cai Ming, Li Zhou-li, Jin Hai-long, Hong Xin, Chen Chang-qing, Shi Bing-yi. Methylprednisolone therapy for severe pulmonary infection after kidney transplantation[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(5): 742-747.

Figures/Tables 3

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