Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (42): 7835-7838.doi: 10.3969/j.issn.1673-8225.2011.42.011

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Feasibility of silk fibroin proteins used in periodontal tissue engineering

Cui Ju-ping, Wang Xin, Zou Jian-ming   

  1. Department of Stomatology, Third People’s Hospital of Wuxi City, Wuxi  214031, Jiangsu Province, China
  • Received:2011-04-16 Revised:2011-05-23 Online:2011-10-15 Published:2011-10-15
  • Contact: Wang Xin, Master, Attending physician, Department of Stomatology, Third People’s Hospital of Wuxi City, Wuxi 214031, Jiangsu Province, China wangxin1975@ gmail.com
  • About author:Cui Ju-ping, Attending physician, Department of Stomatology, Third People’s Hospital of Wuxi City, Wuxi 214031, Jiangsu Province, China

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Abstract:

BACKGROUND: Silk fibroin protein is a new type of biomaterial that is beneficial to the adhesion and growth of skin cells, fibroblasts, osteoblasts, endothelial cells, and glial cells.
OBJECTIVE: To evaluate the feasibility of the silk fibroin protein as an ideal scaffold material for periodontal tissue engineering.
METHODS: Silk fibroin protein composite scaffolds were prepared through a freeze-drying method. The periodontal ligament cells (2×107/L) were collected and seeded on three-dimensional framework of silk fibroin protein (1%, 10%, 50%, 100%). The cell growth and the influences of the silk fibroin protein extracts on cell proliferation and differentiation were observed. 
RESULTS AND CONCLUSION: The periodontal ligament cells adhered and proliferated on the three-dimensional framework of silk fibroin protein, the different concentrations of silk fibroin protein extracts had no influences on the cell proliferation and differentiation. Silk fibroin protein can be used as an ideal scaffold material for cell adhesion and growth in periodontal tissue engineering.

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