Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (40): 7581-7584.doi: 10.3969/j.issn.1673-8225.2011.40.040

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Biological characteristics and clinical application of endothelial progenitor cells

Du Li, Liu Kang-ding   

  1. Department of Neurology, the First Hospital of Jilin University, Changchun  130021, Jilin Province, China
  • Received:2011-01-11 Revised:2011-04-26 Online:2011-10-01 Published:2011-10-01
  • Contact: Liu Kang-ding, Doctoral supervisor, Chief physician, Department of Neurology, the First Hospital of Jilin University, Changchun 130021, Jilin Province, China kangdingliu@163.com
  • About author:Du Li★, Studying for master’s degree, Physician, Department of Neurology, the First Hospital of Jilin University, Changchun 130021, Jilin Province, China duli080608@126.com
  • Supported by:

    the National Natural Science Foundation of China, No.30770755*

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Abstract:

BACKGROUND: Endothelial progenitor cells have been widely used in the research of ischemic diseases, and they can promote endothelial regeneration, repair vessels and promote new vessels formation in tissue.
OBJECTIVE: To review research progress in biological characteristics and clinical application of endothelial progenitor cells.
METHODS: We retrieved PubMed database with the key words of “endothelial progenitor cells, ischemic cerebrovascular disease, early endothelial progenitor cells, late endothelial progenitor cells” for relevant articles published from January 1997 to December 2010. Totally 219 literatures were screened out by computer, and finally 28 papers were involved in the analysis.
RESULTS AND CONCLUSION: Endothelial progenitor cells are found in fetal liver, human umbilical cord blood, adult peripheral blood and bone marrow. Endothelial progenitor cells from human umbilical cord blood and peripheral blood are derived from bone marrow. In addition, in the heart, blood vessels, adipose tissue and skeletal muscle tissues, there is also presence of endothelial progenitor cells. Endothelial progenitor cells can promote endothelial regeneration, repair vessels and promote new vessels formation in tissue. They play an important role in fighting against stent restenosis. Compared to early endothelial progenitor cells, late endothelial progenitor cells are more likely to form capillaries, and have a wide range of application prospects for stem cell transplantation in the treatment of cerebral ischemic stroke.

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