Abstract:

BACKGROUND: Wear particles are the important potential factor leading to periprosthetic osteolysis, but the cause of periprosthetic osteolysis and its development process are still unclear.
OBJECTIVE: To analyze the vale of pathological examination in the diagnosis of infection after total joint arthroplasty based on review of pathological sections after total joint arthroplasty.
METHODS: The first author searched PubMed and CNKI databases (1990/2008) for articles about loosening bone around the implanted hip prosthesis and relevant pathological changes.
RESULTS AND CONCLUSION: The gap between the prosthesis and bone is filled with the interface membrane, and wear particles induce the interface membrane to release inflammatory cytokines leading to loosening prosthesis. To minimize wear debris generation can reduce the release of inflammatory neurotransmitters. The incidence of loosening prosthesis after total joint arthroplasty can be reduced by decreasing the osteolytic changes of the interface membrane.