Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (38): 7132-7134.doi: 10.3969/j.issn.1673-8225.2011.38.023

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Esophageal repairing acellular biological tissues fixed by EX-810

Li Li1, Gu Zhi-peng2, Chen Jian1, Yu Xi-xun2   

  1. 1Department of Oncology, the 452 Hospital of Chinese PLA, Chengdu  610021, Sichuan Province, China
    2Department of Medical Polymer and Artificial Organs, College of Polymer Science and Engineering, Sichuan University, Chengdu  610065, Sichuan Province, China
  • Received:2011-03-09 Revised:2011-05-07 Online:2011-09-17 Published:2011-09-17
  • Contact: Yu Xi-xun, Associate professor, Master’s supervisor, Department of Medical Polymer and Artificial Organs, College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, Sichuan Province, China yuxixun@163.com
  • About author:Li Li★, Master, Attending physician, Department of Oncology, the 452 Hospital of Chinese PLA, Chengdu 610021, Sichuan Province, China lzslili@sina.com
  • Supported by:

    the Scientific Research Project of Sichuan Health Bureau, No. 100194*; the Science and Technology Tackle Key Program of Sichuan Province, No. 05SG022-022*

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Abstract:

BACKGROUND: Natural biological tissue materials can be gradually absorbed, and can induce tissue-specific remodeling, which are ideal esophageal repair materials.
OBJECTIVE: To investigate the characteristics of porcine esophageal tissues fixed with ethylene glycol diglycidyl ether (EX-810).
METHODS: The porcine esophageal tissues were treated with 4% EX-810 for 1 hour to 120 hours, and then they were examined morphologically with the electron microscope. The fixation index determination and the biomechanics test were also performed to study the degree of cross-linking and the effect of cross-linking on the mechanical properties.
RESULTS AND CONCLUSION: The antigenicity of esophageal tissues could be diminished by EX-810 through getting rid of cells in the esophageal tissues or reducing the level of free amino groups in the esophageal tissues. The structural integrity of collagen in esophageal tissues could be preserved after treating with EX-810. In this study, it was also found that the EX-810-fixed porcine esophageal tissues showed better mechanical properties than the native esophageal tissues, and had a changed stress-strain characteristics. It could meet the standard used as the prosthetic materials for bridging esophageal defects. The EX-810-fixed porcine esophageal tissues showed low antigenicity and proper mechanical properties, and the structural integrity of collagen in them could also be preserved.

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