Abstract:

BACKGROUND: Insulin as one of the components of microencapsulation carrier preparation for in situ stereotype can promote the ulcer healing.
OBJECTIVE: To evaluate the therapeutic effect of microencapsulation carrier preparation for in situ stereotype on skin ulcers of diabetic rats.
METHODS: Sprague-Dawley (SD) rats were used to establish diabetic rat models by intraperitoneal injection of streptozotocin (STZ) and to set up skin ulcer models by surgical methods. All rats were randomly divided into 4 groups by different interventions:  microencapsulation preparation with effective component group (MPE), microencasultion preparation without effective component group (MPNE), general preparation with effective component group (GE), blank control group (BC). Ulcer area was measured at regular time intervals. In the first 14 days, full-thickness skin wounds were brought to make histological observation and determine the positive cell numbers expressing epidermal growth factor receptor (EGFR) and fibronectin (FN) .
RESULTS AND CONCLUSION: The skin ulcer healing time of MPE group was the shortest compared with the other three groups (P < 0.05 or P < 0.01). The number of EGFR and FN positive cells in MPE group was more than that of any other three groups (P < 0.05 or P < 0.01). Microencapsulation carrier preparation for in situ stereotype can promote the healing course of skin ulcer in diabetic rats.