Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (36): 6809-6812.doi: 10.3969/j.issn.1673-8225.2011.36.037

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Application of umbilical cord blood mesenchymal stem cells in cartilage tissue engineering

Wang Cong-ren, Zhang Shou   

  1. Department of Orthopedics, Xiangya Haikou Hospital (Haikou People’s Hospital), Central South University, Haikou  5720208, Hainan Province, China
  • Received:2011-03-11 Revised:2011-05-25 Online:2011-09-03 Published:2011-09-03
  • Contact: Zhang Shou, Chief physician, Master’s supervisor, Department of Orthopedics, Xiangya Haikou Hospital (Haikou People’s Hospital), Central South University, Haikou 5720208, Hainan Province, China
  • About author:Wang Cong-ren★, Studying for master’s degree, Department of Orthopedics, Xiangya Haikou Hospital (Haikou People’s Hospital), Central South University, Haikou 5720208, Hainan Province, China wangcongren1010@sina.com
  • Supported by:

    the Natural Science Foundation of Hainan Province, No. 309107*; Haikou Key Science and Technology Porject, No. 2010-168*

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Abstract:

BACKGROUND: Due to the poor repair capacity of articular cartilage, it is still a difficult problem to repair and reconstruct articular cartilage defects in orthopedics, and it is also one of the research foci in recent years. But, the development of cartilage tissue engineering provides a new way for repairing articular cartilage defects.
OBJECTIVE: To conclude and analyze the biological characteristics of umbilical cord blood mesenchymal stem cells and their research and application in cartilage tissue engineering.
METHODS: We searched CNKI and PubMed database for literatures from January 2000 to December 2010. Key words were “umbilical cord blood mesenchymal stem cells, tissue engineering, cartilage repair”. Articles on Umbilical cord blood mesenchymal stem cells and cartilage tissue engineering were included, and repetitive studies were excluded. Finally, 33 articles were selected for further analysis.
RESULTS AND CONCLUSION: Umbilical cord blood mesenchymal stem cells, as ideal seed cells of cartilage tissue engineering, are easy to obtain, and have weak immunogenicity, strong differentiation, low rate of bacterial contamination by viruses and other unique advantages. And it is will play an important role in cartilage tissue engineering.

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