Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (34): 6339-6341.doi: 10.3969/j.issn.1673-8225.2011.34.017

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Hemolysis phenomenon of pure magnesium and two different coating pure magnesium

Zhao Gang1, Wu Yan-juan1, Hu Jin2, Liu Guang-yi2, Li De-chao1   

  1. 1School of Stomatology, Jiamusi University, Jiamusi  154007, Heilongjiang Province, China
    2School of Materials Science and Engineering, Harbin Institute of Technology, Harbin  150001, Heilongjiang Province, China
  • Received:2011-02-10 Revised:2011-03-10 Online:2011-08-20 Published:2011-08-20
  • Contact: Li De-chao, Doctor, Professor, School of Stomatology, Jiamusi University, Jiamusi 154007, Heilongjiang Province, China dechaoli2004@yahoo.com.cn
  • About author:Zhao Gang★, Master, Associate professor, School of Stomatology, Jiamusi University, Jiamusi 154007, Heilongjiang Province, China zhaogangkq@126.com
  • Supported by:

    Science and Technology Project of Health Department of Heilongjiang Province, No. 2009-36*; Science and Technology Research Project of Jiamusi University, No. S22009-001*

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Abstract:

BACKGROUND: Although magnesium as implant material which has good biocompatibility and biodegradable absorption. However, excessive corrosion of magnesium will cause rapid decrease of the mechanical properties before rehabilitation of bone tissue.
OBJECTIVE: To detect the blood-compatibility of pure magnesium (MG), micro-arc oxidized magnesium (MAO) and dicalcium phosphate dihydrate coating formed on micro-arc oxidized magnesium (DCPD).
METHODS: MG, MAO and DCPD extracts were contacted with anticoagulation dilution rabbit blood. Sodium Chloride was used in negative control group; distilled water was used in positive control group. Centrifuged after mixing, the optical density value of supernatant was determined by spectrophotometer, and hemolytic rate was counted.
RESULTS AND CONCLUSION: Hemolytic rate of untreated pure magnesium extract group was 52.34%; the MAO and DCPDC extract group were 0.32% and 0.14%. Hemolytic rate of negative and positive group were 0% and 100%. The untreated pure magnesium showed a serious hemolysis. However, MAO and DCPD have excellent blood-compatibility, hemolytic rate is less than 5%, and they conform to the national standard requirement.

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