Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (32): 6072-6076.doi: 10.3969/j.issn.1673-8225.2011.32.042

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Cardiac electrophysiological characteristics after transplantation of differentiated bone marrow mesenchymal stem cells

Liu Bo-wu, Lü An-lin, Yan Xue-bo, Huang Wei, Hou Jing, Li Yao   

  1. Department of Cardiology, Xijing Hospital Affiliated to Fourth Military Medical University, Xi’an  710032, Shaanxi Province, China
  • Received:2011-02-18 Revised:2011-03-22 Online:2011-08-06 Published:2011-08-06
  • Contact: Lü An-lin, Associate chief physician, Associate professor, Department of Cardiology, Xijing Hospital Affiliated to Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China lvanlin@fmmu.edu.cn
  • About author:Liu Bo-wu★, Master, Department of Cardiology, Xijing Hospital Affiliated to Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China liubowu@fmmu.edu.cn

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Abstract:

BACKGROUND: With the development of biotechnology, the electrophysiology of repairing heart tissues of myocardial infarction or myocardial hypertrophy by using bone marrow mesenchymal stem cell has become a hot spot.
OBJECTIVE: To overview the research progress of cardiac electrophysiological characteristics after transplantation of induced differentiation of bone marrow mesenchymal stem cells into cardiomyocytes.
METHODS: The databases of PubMed, Springer Link, Science Direct and CNKI were retrieved for papers published from January 2000 to October 2010 with the key words of “bone marrow mesenchymal stem cells, cardiac/heart, electrophysiology/electrophysiological characteristics”. The relevant articles concerning cardiac electrophysiological characteristics of induce differentiation and transplantation of bone marrow stem cells were collected.
RESULTS AND CONCLUSION: Totally 208 papers have been searched. Preliminary screening by reading abstracts to exclude 162 papers that study purpose do not coincident with this review either contents duplicated, and internalized 46 papers at last. Bone marrow mesenchymal stem cells after induced differentiation and transplantation could improve heart function of animal experimental model and myocardial infarction or myocardial hypertrophy patients. Although the cardiomyocyte-like cells from bone marrow mesenchymal stem cells could help to improve heart function, the cardiac electrophysiological characteristics may be influenced by them.

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