Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (34): 6323-6327.doi: 10.3969/j.issn.1673-8225.2010.34.013

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Preparation and bioactivity of nano-hydroxyapatite/polyvinyl alcohol-hydrogel composite

Wu Gang1, Zhao Chun-hua1, Wang Cheng-tao2, Zhang Wen-guang2   

  1. 1 College of Mechanical and Material Engineering, China Three Gorges University, Yichang   443002, Hubei Province, China; 2 School of Mechanical and Power Engineering, Shanghai Jiao Tong University, Shanghai   200030, China
  • Online:2010-08-20 Published:2010-08-20
  • About author:Wu Gang☆, Doctor, College of Mechanical and Material Engineering, China Three Gorges University, Yichang 443002, Hubei Province, China wwwg2000@sina.com.cn
  • Supported by:

     the National Natural Science Foundation of China, No. 50905097/ E050504*; a grant by Hubei Provincial Education Ministry, No. Q20091306*

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Abstract:

BACKGROUND: Previous studies have shown that, nano-hydroxyapatite/polyvinyl alcohol hydrogel (nano-HA/PVA-H) composite exhibits good mechanical property, friction and ware resistance, indicating early load capacity and good bioactivity of HA/PVA-H composite. Does HA/PVA-H composite material form binding activity with surrounding bone tissues through HA particles?
OBJECTIVE: To prepare the nano-HA/PVA-H composite and to evaluate the biological property of the material.
METHODS: After Ca(OH)2 grinding, suspended dispersion solution was made at a certain concentration; adding an appropriate amount of 15% mass fraction PVA aqueous solution, then dimethyl sulfoxide, finally H3PO4 ethanol solution at Ca/P ratio of 1.67: 1. The HA/PVA-H composite was prepared and processed into in vitro simulated body fluid test. Changes of simulated body fluid solution before and after soaking process were investigated. Scanning electron microscopy, FTIR and XRD were used to characterize the structure and component of composite materials.
RESULTS: Scanning electron microscopy showed that, nano-size crystals were formed on the surface of HA/PVA-H after soaking. XRD analysis proved that these crystals were HA particles. The pH value of simulated body fluid solution, and concentrations of Ca and P ions were decreased after soaking. Characteristic peaks of PO4 3- were enhanced and new peaks of CO3 2- were found after soaking on the FTIR experiments. Results showed that HA/PVA-H composite materials have good bioactivities.

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