Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (34): 6328-6332.doi: 10.3969/j.issn.1673-8225.2010.34.014

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Structure and properties of biodegradable, porous starch/polyvinyl alcohol composite membrane

Zhu Ai-chen1, Shi Rui2, Yuan Run-ying2, Chen Da-fu2, Zhang Li-qun1   

  1. 1 Advanced Elastomer Material Research Center, College of Material Science and Technology, Beijing University of Chemical Technology, Beijing   100029, China; 2 Laboratory of Bone Tissue Engineering, Beijing Research Institute of Traumatology and Orthopaedics, Beijing   100035, China
  • Online:2010-08-20 Published:2010-08-20
  • Contact: Zhang Li-qun, Doctor, Professor, Advanced Elastomer Material Research Center, College of Material Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China
  • About author:Zhu Ai-chen★, Master, Advanced Elastomer Material Research Center, College of Material Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China sunshinebuct@ gmail.com
  • Supported by:

    Natural Science Foundation of Beijing, No. 2102020*; Youth Scientific Research Fund by Beijing Municipal Health Bureau and Beijing Municipal Administration of Traditional Chinese Medicine, No.2009-016*

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Abstract:

BACKGROUND: The starch/polyvinyl alcohol (PVA) membrane was prepared to verify whether its property can meet the requirements of guided tissue regeneration membrane. Previous experiments have investigated the influence of preparation techniques on membrane performance.
OBJECTIVE: To observe the cross-section structure, biocompatibility and in vitro degradation of the starch/PVA membrane at the optimal preparation conditions.
METHODS: Biodegradable and porous starch/PVA membrane was prepared by solution casting and freeze-dried. At pre-freezing temperature -30 ℃ and the solution concentration 5%, PVA and starch mass ratio of 4:1 and 1:1, respectively, the prepared starch/PVA membrane was determined.
RESULTS AND CONCLUSION: The interconnected porous structure was formed in the starch/PVA membrane, the pore size of starch/PVA membrane at 1:1 ratio was greater than that at 4:1. Both L929 cells and MC3T3 cells could grow in the membrane surface. The degradation rate of starch/PVA membrane can be regulated by the repairing rate of different tissues to meet the repair requirement.

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