Chinese Journal of Tissue Engineering Research ›› 2013, Vol. 17 ›› Issue (8): 1344-1348.doi: 10.3969/j.issn.2095-4344.2013.08.003

Previous Articles     Next Articles

Bio-oss combined with fibrin glue and bone morphogenetic protein-2 to repair mandibular defects

Tian Gang, Xu Xiao-gang, Zhou Zhong-hua, Gao Jian-yong   

  1. Department of Stomatology, Changhai Hospital, Second Military Medical University of Chinese PLA, Shanghai 200433, China
  • Received:2012-04-16 Revised:2012-05-11 Online:2013-02-19 Published:2013-02-19
  • About author:Tian Gang★, Master, Attending physician, Lecturer, Department of Stomatology, Changhai Hospital, Second Military Medical University of Chinese PLA, Shanghai 200433, China freetgzhy@sohu.com

Abstract:

BACKGROUND: Bio-oss granular structure is normally used for hole-shaped defects in the form of filling transplantation, but it is difficult to forming for more than three-wall defects.
OBJECTIVE: To evaluate the osteogenic activities of Bio-oss after combination with fibrin glue and bone morphogenetic protein-2 in the repair of canine mandibular defects.
METHODS: The second and fourth premolar teeth and the second molar teeth were extracted bilaterally in nine hybrid canines, resulting in 1 cm × 1 cm bone defect. Bio-oss, Bio-oss+fibrin glue and Bio-oss+fibrin glue+bone morphogenetic protein-2 were implanted into bone defects of the second, fourth premolar teeth and the second molar teeth, respectively.
RESULTS AND CONCLUSION: Stage Ⅰ healing of soft tissues was achieved in all animals. Bio-oss was closely combined with fibrin glue, which was difficult to be separated. The proportion of new bone was higher in the Bio-oss+fibrin glue+bone morphogenetic protein-2 group than in the other two groups at 4, 8, and 12 weeks after extraction (P < 0.05). It shows that fibrin glue can solve the difficulty in Bio-oss formation, and Bio-oss combined with bone morphogenetic protein-2 can promote osteogenic activities.

Key words: biomaterials, tissue engineering bone materials, tissue engineering cartilage materials, fibrin glue, bone morphogenetic protein, inorganic bovine bone, mandibular defects, modeling, provincial grants-supported paper, biomaterial photographs-containing paper

CLC Number: