Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (20): 3649-3652.doi: 10.3969/j.issn.1673-8225.2011.20.010

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Effects of resistance exercise on insulin-like growth factor 1 and myostatin in the skeletal muscle of rats

Wang Jing, Lu Jian   

  1. College of Physical Education and Health, East China Normal University, Shanghai  200241, China
  • Received:2011-03-04 Revised:2011-04-01 Online:2011-05-14 Published:2011-05-14
  • Contact: Lu Jian, Professor, College of Physical Education and Health, East China Normal University, Shanghai 200241, China jlu@tyxx.ecnu.edu.cn
  • About author:Wang Jing☆, Studying for doctorate, College of Physical Education and Health, East China Normal University, Shanghai 200241, China applytq@126.com

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Abstract:

BACKGROUND: Most of the benefits of resistance training are related to muscle hypertrophy. However, the effects of resistance exercise on the positive and negative regulatory factors of hypertrophy in the skeletal muscle are unclear.
OBJECTIVE: To investigate the effects of resistance exercise on insulin-like growth factor 1 (IGF-1) and myostatin in the skeletal muscle using a rat model of climbing ladder with a load.
METHODS: The SD rats were divided into exercise and control groups randomly, and the exercise group took 10 weeks resistance exercise. The resistance training consisted of climbing a ladder carrying a load suspended from the tail. The weights were increased gradually from 30% body weight to 200% body weight. The IGF-1peptide and mRNA of myostatin were observed by immunohistochemistry (IHC) and RT-PCR respectively.
RESULTS AND CONCLUSION: IGF-1peptide increased significantly and myostatin mRNA decreased significantly in the skeletal muscle in the exercise group. It is concluded that IGF-1and myostatin are very sensitive to resistance exercise and works at the same time. IGF-1and myostatin play opposite roles in the adaptation of muscle to exercise.

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