Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (27): 5103-5107.doi: 10.3969/j.issn.2095-4344.2012.27.031

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Mechanism underlying endogenous neural stem cells migration following ischemic brain damage and the regulatory effect of traditional Chinese medicine

Su Xiao-hui1,2, Kong Xiang-ying1, Lin Na1   

  1. 1Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;
    2Chengde Medical College, Chengde 067000, Hebei Province, China
  • Received:2011-12-07 Revised:2012-02-23 Online:2012-07-01 Published:2013-11-01
  • Contact: Kong Xiang-ying, M.D., Researcher assistant, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China kongu0051@163.com

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Abstract:

BACKGROUND: Migration of endogenous neural stem cells (NSCs) caused by ischemic brain injury has been a spot light in neuroscience. After ischemic brain injury, neuron becomes swelling and necrotic due to ischemia and hypoxia. NSCs that migrated to the necrosis area driven by a variety of factors can repair the brain tissue and make neural function recovered partially.
OBJECTIVE: To review the mechanism underlying NSCs migration caused by ischemic brain injury and the regulatory effects of traditional Chinese medicine.
METHODS: A computer-based retrieval of PubMed Database, Chinese Journal Full-text Database, China Doctor Dissertations Full-text Database and China National Knowledge Infrastructure to search articles describing the mechanism underlying NSCs migration caused by ischemic brain injury and the regulatory effects of traditional Chinese medicine published from 2000 to 2011 using the key words “cerebral ischemia, endogenous neural stem cells, migration, traditional Chinese medicine”. The repetitive studies were excluded. The retrieved literatures contained original articles, thesis and reviews.
RESULTS AND CONCLUSION: A great number of articles have proven that NSCs migrate to the lesion site after brain injury. Factors such as cytokines, growth factors, chemotactic factors and inflammatory factors are involved in the migration of NSCs. Also, many studies have also confirmed that traditional Chinese medicine plays an important role in regulating the migration of endogenous NSCs.

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