Abstract:

BACKGROUND: Introperative peritoneal hyperthermia chemotherapy (IPHC) using interaction of regional high-dose chemotherapy and hyperthermia induce apoptosis and necrosis of intraoperative tumor cells. Its clinical effect has been confirmed around the world. However, current IPHC machine has low control accuracy and its therapeutic efficacy is not ideal.
OBJECTIVE: To design a kind of IPHC machine system based on F2812 and computational fluid dynamics (CFD) simulation and optimize its parameters to have best temperature control and therapeutic effects.
METHODS: Control system of heating and circulation based on DSP F2812 had fast response and high temperature control accuracy. Optimize parameter could be obtained by tuning PID algorithm. CFD simulation of Intraperitoneal temperature field and velocity vector field were calculated by FLUENT. Three kind of introperative peritoneal piping mode were compared to find the best strategy. Peritoneal temperature distribution was given.
RESULTS AND CONCLUSION: The temperature acquisition and control module was designed, and the temperature control accuracy was ±0.3 ℃. Optimization results showed that 3 inflows and 2 outflows with closed cavity can meet operation requirements. Peritoneal temperature distribution in 3D is also given.