Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (11): 1937-1940.doi: 10.3969/j.issn.1673-8225.2011.11.009

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Comparison of reverses mechanical characteristics of the femur in osteoporosis rats treated with four kinds of medicines

Zhao Bao-lin1, Quan Tie-gang1, Ma Hong-shun2   

  1. 1China-Japan Union Hospital of Jilin University, Changchun  130031, Jilin Province, China
    2Department of Engineering Mechanics, Nanling Campus, Jilin University, Changchun  130022, Jilin Province, China
  • Received:2010-10-08 Revised:2010-12-19 Online:2011-03-12 Published:2011-03-12
  • Contact: Zhao Bao-lin, Professor, China-Japan Union Hospital of Jilin University, Changchun 130031, Jilin Province, China mahs@jlu.edu.cn
  • About author:Zhao Bao-lin, Professor, China-Japan Union Hospital of Jilin University, Changchun 130031, Jilin Province, China mahs@jlu.edu.cn

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Abstract:

BACKGROUND: The prevention, diagnosis and treatment for osteoporosis need to understand the effect of medicine treatment. The reverses mechanical characteristics index is a reliable method for evaluating quality of osteoporosis after drug treatment.
OBJECTIVE: To observe the therapeutic effect of several drugs on the treatment of osteoporosis.
METHODS: Female Wistar rats, with 4-5 months old, were established osteoporosis models and treated by traditional Chinese medicinal compound preparations (TCMCPs), alendronate, vitamin K and calcium. All rats were sacrificed at 15 weeks after medication. The femur of rats were tested by a torsion test machine at speed of 1 (°)/s. The torque and torsion angle were read, and the fracture surface was observed after sample failure.
RESULTS AND CONCLUSION: The maximum torque, the biggest angle of torsion, and the biggest shear stress of the osteoporosis rats were smaller than those of the normal rats (P < 0.05). After TCMCPs or alendronate treatment, the maximum torque, the biggest angle of torsion, and the biggest shear stress revived to normal levels, but vitamin K and calcium had no obviously effect on reverses mechanical characteristics. The anti-torsional section coefficient was not affected by model preparation or medication. The findings demonstrated that TCMCPs, alendronate, and vitamin K have certain curative effect on treating osteoporosis, the calcium effect is not obvious, and the TCMCPs is best.

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