Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (10): 1875-1878.doi: 10.3969/j.issn.1673-8225.2011.10.037

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miRNA and biological behavior of stem cells

Zhang Zi-qiang, Liu Yu-mei, Deng Wen, Lü Qiong-xia   

  1. College of Animal Science and Technology, Henan University of Science and Technology, Luoyang   471003, Henan Province, China
  • Received:2010-11-08 Revised:2010-12-09 Online:2011-03-05 Published:2011-03-05
  • About author:Zhang Zi-qiang★, Master, Lecturer, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, Henan Province, China lymzq@126.com
  • Supported by:

    Startup Foundation for Doctors of Henan University of Science and Technology, No. 09001424*

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Abstract:

BACKGROUND: In the past, the research about stem cells was focused on the genes. But now, more and more evidence indicate that miRNA plays an important regulatory role in the self-renewal and differentiation process of stem cells.
OBJECTIVE: To introduce the formation of miRNA and its effect on the self-renewal and multi-directional differentiation of stem cells.
METHODS: A computer based online search of Elsevier database (2000-01/2010-05) was performed with the key words “microRNA, stem cell” in English. Simultaneously, “microRNA, stem cell” in Chinese was used to search CNKI database (2000-01/2010-05).
RESULTS AND CONCLUSION: There are self specific miRNA express spectra and sequence signature of different cells in different tissues, and they can serve as specific molecule marks of some tissues or cells. In the different cell developmental stage, there are different miRNA, and they determine cell differentiation direction and differentiation phase as a switch of timing and direction location differentiation. There are self specific miRNA in various kinds of stem cells, and there are also specific miRNA expressions in different differentiation stage of stem cells. They play a critical role in the maintenance of stem cell self-renewal and multi-directional differentiation characteristics. MiRNA as a new regulator RNA of gene expression provides a new way for the research of stem cells.

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