Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (37): 6891-6894.doi: 10.3969/j.issn.1673-8225.2010.37.012

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Effects of compound tea polyphenol ointment on wound healing and epidermal growth factor expression of radiation-induced cervical skin dermatitis in rats

Xue Li1, Feng Zhi-ming2, Yi Yin-sha2, Yan Zheng-li2, Li Xu-hong1　   

  1. 1 Third Hospital of Xiangya, Central South University, Changsha  410013, Hunan Province, China; 2 Department of Pharmaceutical Engineering, Hunan Normal University, Changsha  410081, Hunan Province, China
  • Online:2010-09-10 Published:2010-09-10
  • Contact: Feng Zhi-ming, Associate professor, Department of Pharmaceutical Engineering, Hunan Normal University, Changsha 410081, Hunan Province, China fengzhiming@163.com
  • About author:Xue Li, Associate professor, Third Hospital of Xiangya, Central South University, Changsha 410013, Hunan Province, China li0901@xy3yy.com
  • Supported by:

    the Scientific Research Planning Project for Traditional Chinese Medicine in Hunan Province, No. 2008096*; Science and Technology Planning Project of Hunan Province, No. 2009SK3171*

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Abstract:

BACKGROUND: Studies demonstrated that compound tea polyphenol ointment promotes wound healing in radiation-induced cervical skin dermatitis, but the precise mechanisms remain poorly understood. 
OBJECTIVE: To study the effects of compound tea polyphenol ointment on wound healing rate and epidermal growth factor (EGF) expression of radiation-induced dermatitis in rats.
METHODS: Adult Wistar rats were randomly divided into 3 groups. Rats in the experimental and control groups were established 60Coγ radiation-induced dermatitis models and treated by compound tea polyphenol ointment or Vaseline, respectively. In the simple wound group, 1.5-cm2 skin of rats were removed and treated by routine nursing care. The EGF expression in wound tissue was analyzed by radioimmunoassay, and the wound healing rate and wound healing time was also measured at 5, 10, 20, 30 and 40 days after radiation.
RESULTS AND CONCLUSION: The EGF expressions of wound skin tissues in the experiment and control groups were higher than that of the simple wound group at 5 days after radiation, which revealed that the radiodermatitis was different from simple wound and healed slowly. Compared with the control group, the EGF expression of wound skin tissues in the experiment group was significantly higher (P < 0.05) and the wound healing rate was significantly greater at 10 and 20 days after radiation(P < 0.05). The wound healing time of the experiment groups was significantly shorter than that of the control group (P < 0.05). But the wound healing time of the experiment and control groups was longer that that of the simple wound group (P < 0.05). Compound tea polyphenol ointment can significantly promote the wound healing of radiation-induced dermatitis in rats, which may be related to accelerating the EGF expression of wound skin tissues.

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